Assessment of cardiac vagal activity in patients with hyperthyroidism

Maria Vittoria Pitzalis, Filippo Mastropasqua, Francesco Massari, Anna Ciampolillo, Andrea Passantino, Matteo Ognissanti, Antonella Mannarini, Domenico Zanna, Riccardo Giorgino, Paolo Rizzon

Research output: Contribution to journalArticlepeer-review


Previous studies suggested that in patients with hyperthyroidism an autonomic imbalance and in particular a lower than normal vagal activity might be present. To verify this hypothesis we have evaluated the respiratory sinus arrhythmia (RSA, a measure of cardiac vagal activity) in ten hyperthyroid patients and in ten normal subjects. RSA was calculated from the power of the spectral component of the heart rate variability in high frequency band (HF-RR) during both spontaneous (supine and passive head-up tilt) and controlled breathing (supine). During controlled breathing the phase relation between heart rate and respiratory has been computed. The hyperthyroid patients showed a higher heart rate in all three conditions (P

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - Apr 1 1998


  • Heart rate variability
  • Hyperthyroidism
  • Respiratory sinus arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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