Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder

Michele Terzaghi, Gianpaolo Toscano, Francesca Casoni, Marta Picascia, Dario Arnaldi, Valter Rustioni, Maurizio Versino, Elena Sinforiani, Raffaele Manni

Research output: Contribution to journalArticle

Abstract

To search for a specific neuropsychological profile in idiopathic REM sleep behavior disorder (iRBD), able to predict the onset of neurodegenerative disorders.In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7 ± 3.8 years), the baseline cognitive profile of converters to neurodegenerative disease was compared with that of the nonconverters. Five cognitive domains were assessed: memory, attention-working memory, executive functions, visuospatial abilities, language. Mild cognitive impairment (MCI) was diagnosed according to the Movement Disorder Society’s diagnostic criteria for Parkinson’s disease.30 subjects (47.6\ developed a neurodegenerative disease (latency to conversion 60.33 ± 44.81 months). MCI was found in 50\% of the converters and 12\% of the nonconverters (p = .001), and its presence conferred a neurodegenerative disease risk of 10\% at 3 years, 36\% at 5 years, and 73\% at 10 years (p = .002). Pathological equivalent scores on at least one neuropsychological test were detected in 46.7\% of the converters versus 21.2\% of the nonconverters in the memory domain (p = .032), in 40.0\% versus 6.1\% in that of executive functions (p = .002), and in 20.0\% versus 3\% in the visuospatial abilities domain (p = .047). On multivariate analysis, impaired executive functions significantly correlated with phenoconversion (p = .018). Lower Mini Mental State Examination (MMSE) scores (p = .004) and memory deficits (p = .031) were found in patients who developed dementia first.Cognitive profile is useful for stratifying risk of phenoconversion in patients with iRBD. The presence of MCI and impaired executive functions, memory, and visuospatial abilities discriminated the converters. Lower MMSE scores and memory deficits may characterize those subjects who first develop dementia.
Original languageUndefined/Unknown
JournalSleep
Volume42
Issue number8
DOIs
Publication statusPublished - Apr 1 2019

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Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder. / Terzaghi, Michele; Toscano, Gianpaolo; Casoni, Francesca; Picascia, Marta; Arnaldi, Dario; Rustioni, Valter; Versino, Maurizio; Sinforiani, Elena; Manni, Raffaele.

In: Sleep, Vol. 42, No. 8, 01.04.2019.

Research output: Contribution to journalArticle

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title = "Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder",
abstract = "To search for a specific neuropsychological profile in idiopathic REM sleep behavior disorder (iRBD), able to predict the onset of neurodegenerative disorders.In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7 ± 3.8 years), the baseline cognitive profile of converters to neurodegenerative disease was compared with that of the nonconverters. Five cognitive domains were assessed: memory, attention-working memory, executive functions, visuospatial abilities, language. Mild cognitive impairment (MCI) was diagnosed according to the Movement Disorder Society’s diagnostic criteria for Parkinson’s disease.30 subjects (47.6\ developed a neurodegenerative disease (latency to conversion 60.33 ± 44.81 months). MCI was found in 50\{\%} of the converters and 12\{\%} of the nonconverters (p = .001), and its presence conferred a neurodegenerative disease risk of 10\{\%} at 3 years, 36\{\%} at 5 years, and 73\{\%} at 10 years (p = .002). Pathological equivalent scores on at least one neuropsychological test were detected in 46.7\{\%} of the converters versus 21.2\{\%} of the nonconverters in the memory domain (p = .032), in 40.0\{\%} versus 6.1\{\%} in that of executive functions (p = .002), and in 20.0\{\%} versus 3\{\%} in the visuospatial abilities domain (p = .047). On multivariate analysis, impaired executive functions significantly correlated with phenoconversion (p = .018). Lower Mini Mental State Examination (MMSE) scores (p = .004) and memory deficits (p = .031) were found in patients who developed dementia first.Cognitive profile is useful for stratifying risk of phenoconversion in patients with iRBD. The presence of MCI and impaired executive functions, memory, and visuospatial abilities discriminated the converters. Lower MMSE scores and memory deficits may characterize those subjects who first develop dementia.",
author = "Michele Terzaghi and Gianpaolo Toscano and Francesca Casoni and Marta Picascia and Dario Arnaldi and Valter Rustioni and Maurizio Versino and Elena Sinforiani and Raffaele Manni",
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T1 - Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder

AU - Terzaghi, Michele

AU - Toscano, Gianpaolo

AU - Casoni, Francesca

AU - Picascia, Marta

AU - Arnaldi, Dario

AU - Rustioni, Valter

AU - Versino, Maurizio

AU - Sinforiani, Elena

AU - Manni, Raffaele

PY - 2019/4/1

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N2 - To search for a specific neuropsychological profile in idiopathic REM sleep behavior disorder (iRBD), able to predict the onset of neurodegenerative disorders.In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7 ± 3.8 years), the baseline cognitive profile of converters to neurodegenerative disease was compared with that of the nonconverters. Five cognitive domains were assessed: memory, attention-working memory, executive functions, visuospatial abilities, language. Mild cognitive impairment (MCI) was diagnosed according to the Movement Disorder Society’s diagnostic criteria for Parkinson’s disease.30 subjects (47.6\ developed a neurodegenerative disease (latency to conversion 60.33 ± 44.81 months). MCI was found in 50\% of the converters and 12\% of the nonconverters (p = .001), and its presence conferred a neurodegenerative disease risk of 10\% at 3 years, 36\% at 5 years, and 73\% at 10 years (p = .002). Pathological equivalent scores on at least one neuropsychological test were detected in 46.7\% of the converters versus 21.2\% of the nonconverters in the memory domain (p = .032), in 40.0\% versus 6.1\% in that of executive functions (p = .002), and in 20.0\% versus 3\% in the visuospatial abilities domain (p = .047). On multivariate analysis, impaired executive functions significantly correlated with phenoconversion (p = .018). Lower Mini Mental State Examination (MMSE) scores (p = .004) and memory deficits (p = .031) were found in patients who developed dementia first.Cognitive profile is useful for stratifying risk of phenoconversion in patients with iRBD. The presence of MCI and impaired executive functions, memory, and visuospatial abilities discriminated the converters. Lower MMSE scores and memory deficits may characterize those subjects who first develop dementia.

AB - To search for a specific neuropsychological profile in idiopathic REM sleep behavior disorder (iRBD), able to predict the onset of neurodegenerative disorders.In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7 ± 3.8 years), the baseline cognitive profile of converters to neurodegenerative disease was compared with that of the nonconverters. Five cognitive domains were assessed: memory, attention-working memory, executive functions, visuospatial abilities, language. Mild cognitive impairment (MCI) was diagnosed according to the Movement Disorder Society’s diagnostic criteria for Parkinson’s disease.30 subjects (47.6\ developed a neurodegenerative disease (latency to conversion 60.33 ± 44.81 months). MCI was found in 50\% of the converters and 12\% of the nonconverters (p = .001), and its presence conferred a neurodegenerative disease risk of 10\% at 3 years, 36\% at 5 years, and 73\% at 10 years (p = .002). Pathological equivalent scores on at least one neuropsychological test were detected in 46.7\% of the converters versus 21.2\% of the nonconverters in the memory domain (p = .032), in 40.0\% versus 6.1\% in that of executive functions (p = .002), and in 20.0\% versus 3\% in the visuospatial abilities domain (p = .047). On multivariate analysis, impaired executive functions significantly correlated with phenoconversion (p = .018). Lower Mini Mental State Examination (MMSE) scores (p = .004) and memory deficits (p = .031) were found in patients who developed dementia first.Cognitive profile is useful for stratifying risk of phenoconversion in patients with iRBD. The presence of MCI and impaired executive functions, memory, and visuospatial abilities discriminated the converters. Lower MMSE scores and memory deficits may characterize those subjects who first develop dementia.

U2 - 10.1093/sleep/zsz103

DO - 10.1093/sleep/zsz103

M3 - Articolo

VL - 42

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 8

ER -