Assessment of colorectal hepatic metastases by quantitative T 2 relaxation time

S. Arsalan Raza, L. Funicelli, S. A. Sohaib, D. J. Collins, E. Scurr, M. O. Leach, D. M. Koh

Research output: Contribution to journalArticle

Abstract

Aim: To determine the T 2 relaxation time of colorectal hepatic metastases and changes in T 2 relaxation times following chemotherapy. Materials and methods: 42 patients with 96 hepatic colorectal metastases underwent baseline MRI. Axial T 1, T 2 and multi-echo GRASE sequences were acquired. ROIs were drawn on T 2 relaxation maps, obtained from GRASE images, encompassing metastasis and normal liver to record T 2 relaxation time values. In 11 patients with 28 metastases, MRI was repeated using same protocol at 6 weeks following chemotherapy. The median pre-treatment T 2 values of metastases and normal liver were compared using the Mann-Whitney test. The pre- and post-treatment median T 2 values of metastases were compared using the Wilcoxon-Rank test for responding (n = 16) and non-responding (n = 12) lesions defined by RECIST criteria. The change in T 2 values (ΔT 2) were compared and correlated with percentage change in lesion size. Results: There was no difference in the pre-treatment median T 2 of metastases between responding (67.3 ± 8.6) and non-responding metastases (71.4 ± 16.5). At the end of chemotherapy, there was a decrease in the median T 2 of responding lesions (61.6 ± 12.6) p = 0.83, and increase in non-responding lesions (76.2 ± 18.4) p = 0.03, but these were not significantly different from the pre-treatment values. There was no significant difference in ΔT 2 of responding and non-responding lesions (p = 0.18) and no correlation was seen between size change and ΔT 2 (coefficient = 0.3). Conclusion: T 2 relaxation time does not appear to predict response of colorectal liver metastasis to chemotherapy.

Original languageEnglish
JournalEuropean Journal of Radiology
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Colorectal metastasis
  • Hepatic metastasis
  • MRI
  • T relaxation
  • Tumour therapy response

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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