Introduction: Migraine is a very disabling neurological disorder. Family history can be considered an important risk factor for onset of disease. Clinical data showed indeed a strong hereditary component in migraine with aura, even if the inheritance pattern is complex and internal and external environmental factors may trigger symptoms. Materials and methods: We described a case of a family affected by migraine with aura (average age of 44.5±10.41). The psychological profile was assessed by using Minnesota Multiphasic Personality Inventory-2 (MMPI-2) for analyze the personality profile, Beck Depression Inventory (BDI-II) and Hamilton Rating Scale for anxiety (HAM-A), to assess anxiety and depressive disorders. All patients and 7 sex-aged matched non migraine controls, underwent to Magnetic Resonance Imaging (MRI) examination by using a 3.0 T MR scanner and to Electroencephalography examination. Results: We identified, in our family sample, anxious-depressive symptoms and the tendency to rigidity and distrust in interpersonal relationships. In comparison with control group, we observed an increase of brain normalized volume, peripheral grey and grey matter, although this difference was not significant. Conclusion: The pathophysiology of migraines involves complex and multifactorial factors. Our results suggest an important role of psychological factors and familiar dynamics in the genesis and maintenance of migraine, however the mechanisms underlying this important disorder are presently poorly understood and but issues concerning this topic remain a priority for future research.
- Magnetic Resonance
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