Abstract
The quantitative assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD), allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Invasive techniques, such as intracoronary Doppler ultrasound and the pressure-derived method, which directly assess CFR velocity and fractional flow reserve, have been used for the evaluation of the physiologic significance of coronary lesions. Considerable progress has been made in the improvement of technologies directed toward the noninvasive quantification of myocardial blood flow and CFR. Positron emission tomography has emerged as an accurate technique to quantify CFR. The absolute measurements obtained with this noninvasive approach have been widely validated. Nevertheless, it has not been applied to routine studies because of its high cost and complexity. On the other hand, technetium 99m-labeled tracers have been largely used for the evaluation of myocardial perfusion with single photon emission computed tomography (SPECT) imaging in patients with suspected or known CAD. Recently, attempts to estimate CFR with SPECT tracers have been made to obtain, with noninvasive methods, data for quantitative functional assessment of CAD. This review analyzes the relative merit and limitations of CFR measurements by cardiac SPECT imaging with Tc-99m-labeled tracers and describes the potential clinical applications of this technique.
| Original language | English |
|---|---|
| Pages (from-to) | 456-465 |
| Number of pages | 10 |
| Journal | Journal of Nuclear Cardiology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- coronary flow reserve
- Myocardial blood flow
- SPECT imaging
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers. / Petretta, Mario; Soricelli, Andrea; Storto, Giovanni; Cuocolo, Alberto.
In: Journal of Nuclear Cardiology, Vol. 15, No. 3, 05.2008, p. 456-465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers
AU - Petretta, Mario
AU - Soricelli, Andrea
AU - Storto, Giovanni
AU - Cuocolo, Alberto
PY - 2008/5
Y1 - 2008/5
N2 - The quantitative assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD), allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Invasive techniques, such as intracoronary Doppler ultrasound and the pressure-derived method, which directly assess CFR velocity and fractional flow reserve, have been used for the evaluation of the physiologic significance of coronary lesions. Considerable progress has been made in the improvement of technologies directed toward the noninvasive quantification of myocardial blood flow and CFR. Positron emission tomography has emerged as an accurate technique to quantify CFR. The absolute measurements obtained with this noninvasive approach have been widely validated. Nevertheless, it has not been applied to routine studies because of its high cost and complexity. On the other hand, technetium 99m-labeled tracers have been largely used for the evaluation of myocardial perfusion with single photon emission computed tomography (SPECT) imaging in patients with suspected or known CAD. Recently, attempts to estimate CFR with SPECT tracers have been made to obtain, with noninvasive methods, data for quantitative functional assessment of CAD. This review analyzes the relative merit and limitations of CFR measurements by cardiac SPECT imaging with Tc-99m-labeled tracers and describes the potential clinical applications of this technique.
AB - The quantitative assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD), allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Invasive techniques, such as intracoronary Doppler ultrasound and the pressure-derived method, which directly assess CFR velocity and fractional flow reserve, have been used for the evaluation of the physiologic significance of coronary lesions. Considerable progress has been made in the improvement of technologies directed toward the noninvasive quantification of myocardial blood flow and CFR. Positron emission tomography has emerged as an accurate technique to quantify CFR. The absolute measurements obtained with this noninvasive approach have been widely validated. Nevertheless, it has not been applied to routine studies because of its high cost and complexity. On the other hand, technetium 99m-labeled tracers have been largely used for the evaluation of myocardial perfusion with single photon emission computed tomography (SPECT) imaging in patients with suspected or known CAD. Recently, attempts to estimate CFR with SPECT tracers have been made to obtain, with noninvasive methods, data for quantitative functional assessment of CAD. This review analyzes the relative merit and limitations of CFR measurements by cardiac SPECT imaging with Tc-99m-labeled tracers and describes the potential clinical applications of this technique.
KW - coronary flow reserve
KW - Myocardial blood flow
KW - SPECT imaging
UR - http://www.scopus.com/inward/record.url?scp=44149113532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44149113532&partnerID=8YFLogxK
U2 - 10.1016/j.nuclcard.2008.03.008
DO - 10.1016/j.nuclcard.2008.03.008
M3 - Article
C2 - 18513652
AN - SCOPUS:44149113532
VL - 15
SP - 456
EP - 465
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 3
ER -