Assessment of coronary stenosis, plaque burden and remodeling by multidetector computed tomography in patients referred for suspected coronary artery disease

Giovanni B. Pedrazzini, Ilaria D'Angeli, Giuseppe Vassalli, Francesco F. Faletra, Catherine Klersy, Elena Pasotti, Carlo Corbacelli, Tiziano Moccetti, Angelo Auricchio

Research output: Contribution to journalArticle

Abstract

AIMS: To compare multidetector computed tomography (MDCT) with intravascular ultrasound (IVUS) and invasive quantitative coronary angiography (QCA) for assessment of coronary lesions in patients referred for suspected coronary artery disease (CAD). METHODS AND RESULTS: We studied 57 patients (48 men; mean age: 63 ± 10 years) who underwent 64-slice MDCT because of atypical chest pain, stable angina, or ECG abnormalities and were diagnosed with CAD. All patients subsequently underwent QCA and IVUS. We analyzed 102 coronary lesions using the three techniques. Measurements of luminal area stenosis and cross-sectional area by MDCT (72.9 ± 7.0% and 4.5 ± 1.8 mm, respectively) were in good agreement with those by IVUS [72.7 ± 6.7% and 4.5 ± 1.6 mm, respectively; Lin's concordance correlation coefficient r = 0.847; 95% confidence interval (CI) = 0.792-0.902 and r = 0.931; 95% CI = 0.906-0.956, respectively] but not QCA (r = 0.115; 95% CI = 0.040-0.189 and r = 0.433; 95% CI = 0.291-0.576, respectively). Plaque cross-sectional area and plaque volume measured by MDCT (12.4 ± 3.8 mm and 104.7 ± 52.8 μl, respectively) were in good agreement with those by IVUS (12.2 ± 3.7 mm and 102.8 ± 54.1 μl; r = 0.913; 95% CI = 0.880-0.945 and r = 0.979; 95% CI = 0.969-0.990, respectively). Remodeling index measurements by MDCT (1.22 ± 0.22) were in good agreement with those by IVUS (r = 0.876; 95% CI = 0.831-0.922). Positive remodeling occurred in 63% of stenoses. CONCLUSION: MDCT allows accurate noninvasive assessment of coronary stenosis, plaque burden and remodeling in patients referred for suspected CAD. Positive remodeling is a frequent finding in stable lesions.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalJournal of Cardiovascular Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • computed tomography
  • coronary artery disease
  • intravascular ultrasound
  • quantitative coronary angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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