TY - JOUR
T1 - Assessment of coronary stenosis, plaque burden and remodeling by multidetector computed tomography in patients referred for suspected coronary artery disease
AU - Pedrazzini, Giovanni B.
AU - D'Angeli, Ilaria
AU - Vassalli, Giuseppe
AU - Faletra, Francesco F.
AU - Klersy, Catherine
AU - Pasotti, Elena
AU - Corbacelli, Carlo
AU - Moccetti, Tiziano
AU - Auricchio, Angelo
PY - 2011/2
Y1 - 2011/2
N2 - AIMS: To compare multidetector computed tomography (MDCT) with intravascular ultrasound (IVUS) and invasive quantitative coronary angiography (QCA) for assessment of coronary lesions in patients referred for suspected coronary artery disease (CAD). METHODS AND RESULTS: We studied 57 patients (48 men; mean age: 63 ± 10 years) who underwent 64-slice MDCT because of atypical chest pain, stable angina, or ECG abnormalities and were diagnosed with CAD. All patients subsequently underwent QCA and IVUS. We analyzed 102 coronary lesions using the three techniques. Measurements of luminal area stenosis and cross-sectional area by MDCT (72.9 ± 7.0% and 4.5 ± 1.8 mm, respectively) were in good agreement with those by IVUS [72.7 ± 6.7% and 4.5 ± 1.6 mm, respectively; Lin's concordance correlation coefficient r = 0.847; 95% confidence interval (CI) = 0.792-0.902 and r = 0.931; 95% CI = 0.906-0.956, respectively] but not QCA (r = 0.115; 95% CI = 0.040-0.189 and r = 0.433; 95% CI = 0.291-0.576, respectively). Plaque cross-sectional area and plaque volume measured by MDCT (12.4 ± 3.8 mm and 104.7 ± 52.8 μl, respectively) were in good agreement with those by IVUS (12.2 ± 3.7 mm and 102.8 ± 54.1 μl; r = 0.913; 95% CI = 0.880-0.945 and r = 0.979; 95% CI = 0.969-0.990, respectively). Remodeling index measurements by MDCT (1.22 ± 0.22) were in good agreement with those by IVUS (r = 0.876; 95% CI = 0.831-0.922). Positive remodeling occurred in 63% of stenoses. CONCLUSION: MDCT allows accurate noninvasive assessment of coronary stenosis, plaque burden and remodeling in patients referred for suspected CAD. Positive remodeling is a frequent finding in stable lesions.
AB - AIMS: To compare multidetector computed tomography (MDCT) with intravascular ultrasound (IVUS) and invasive quantitative coronary angiography (QCA) for assessment of coronary lesions in patients referred for suspected coronary artery disease (CAD). METHODS AND RESULTS: We studied 57 patients (48 men; mean age: 63 ± 10 years) who underwent 64-slice MDCT because of atypical chest pain, stable angina, or ECG abnormalities and were diagnosed with CAD. All patients subsequently underwent QCA and IVUS. We analyzed 102 coronary lesions using the three techniques. Measurements of luminal area stenosis and cross-sectional area by MDCT (72.9 ± 7.0% and 4.5 ± 1.8 mm, respectively) were in good agreement with those by IVUS [72.7 ± 6.7% and 4.5 ± 1.6 mm, respectively; Lin's concordance correlation coefficient r = 0.847; 95% confidence interval (CI) = 0.792-0.902 and r = 0.931; 95% CI = 0.906-0.956, respectively] but not QCA (r = 0.115; 95% CI = 0.040-0.189 and r = 0.433; 95% CI = 0.291-0.576, respectively). Plaque cross-sectional area and plaque volume measured by MDCT (12.4 ± 3.8 mm and 104.7 ± 52.8 μl, respectively) were in good agreement with those by IVUS (12.2 ± 3.7 mm and 102.8 ± 54.1 μl; r = 0.913; 95% CI = 0.880-0.945 and r = 0.979; 95% CI = 0.969-0.990, respectively). Remodeling index measurements by MDCT (1.22 ± 0.22) were in good agreement with those by IVUS (r = 0.876; 95% CI = 0.831-0.922). Positive remodeling occurred in 63% of stenoses. CONCLUSION: MDCT allows accurate noninvasive assessment of coronary stenosis, plaque burden and remodeling in patients referred for suspected CAD. Positive remodeling is a frequent finding in stable lesions.
KW - computed tomography
KW - coronary artery disease
KW - intravascular ultrasound
KW - quantitative coronary angiography
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U2 - 10.2459/JCM.0b013e3283403955
DO - 10.2459/JCM.0b013e3283403955
M3 - Article
C2 - 21045721
AN - SCOPUS:79953666511
VL - 12
SP - 122
EP - 130
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 2
ER -