Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach

Cara J. Bossley, Louise Fleming, Nicola Ullmann, Atul Gupta, Alexandra Adams, Prasad Nagakumar, Andrew Bush, Sejal Saglani

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is no agreed upon definition of systemic corticosteroid response in asthmatic children. Moreover, pediatric severe therapy-resistant asthma (STRA) is heterogeneous, and thus response to steroids is unlikely to be uniform in all patients. Objective: We sought to evaluate the utility of a multidomain approach incorporating symptoms, lung function, and inflammation to determine steroid responsiveness in pediatric patients with STRA. Methods: Eighty-two children (median age, 12 years) with STRA received a clinically indicated dose of intramuscular steroid. Changes in 4 separate domains were assessed 4 weeks after intramuscular triamcinolone acetonide: normalization of (1) symptoms (Asthma Control Test score, >19/25 or 50% increase), (2) spirometric results (FEV1 ≥80% of predicted value or ≥15% increase), (3) fraction of exhaled nitric oxide levels (

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
DOIs
Publication statusAccepted/In press - Jul 16 2015

Keywords

  • Inflammation
  • Pediatric
  • Severe asthma
  • Spirometry
  • Steroid response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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