Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: Role of laparoscopy and core needle biopsy

M. Musella, F. Fazioli, S. Lombardi, C. I. Servodio, C. De Martino, V. Iacono, F. Cigala, R. Jovino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression. Methods: The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative-intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging. Results: Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients. Conclusions: High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.

Original languageEnglish
Pages (from-to)1120-1124
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Cyclin D1
  • Laparoscopy
  • Preoperative staging
  • Soft tissue sarcomas

ASJC Scopus subject areas

  • Surgery

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