Assessment of diffusion parameters by intravoxel incoherent motion MRI in head and neck squamous cell carcinoma

Research output: Contribution to journalArticlepeer-review

Abstract

The objectives of this study were to assess the diffusion parameters derived from intravoxel incoherent motion (IVIM) MRI in head and neck squamous cell carcinoma (HNSCC) and to investigate the agreement between different methods of tumor delineation and two numerical methods to extract the perfusion fraction f. Thirty-seven untreated patients with histopathologically confirmed primary HNSCC were included retrospectively in the study. The entire volume of the primary tumor was outlined on diffusion-weighted images using co-registered morphological images as a guide to the tumor location. Apparent diffusion coefficient (ADC) and IVIM diffusion parameters were estimated considering the largest tumor section as well as the entire tumor volume. A bi-exponential fit was implemented to extract f, D (pure diffusion coefficient) and D* (pseudo-diffusion coefficient). A second simplified method, based on an asymptotic extrapolation, was used to determine f. The agreement between ADC and IVIM diffusion parameters derived from the delineation of single and multiple slices, and between the two f estimations, was assessed by Bland-Altman plots. The inter-slice variability of ADC and IVIM diffusion parameters was evaluated. The Kruskal-Wallis test was used to investigate whether the tumor location had a statistically significant influence on the values of the parameters. Comparing the tumor delineation methods, a better accordance was found for ADC and D, with a mean percentage difference of less than 2%. Larger discrepancies were found for f and D*, with mean differences of 4.5% and 5.5%, respectively. When comparing the two f estimation methods, small mean differences were found (

Original languageEnglish
Pages (from-to)1806-1814
Number of pages9
JournalNMR in Biomedicine
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Diffusion-weighted imaging
  • Head and neck cancer
  • Intravoxel incoherent motion imaging
  • Quantitative imaging
  • Tumor delineation

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Assessment of diffusion parameters by intravoxel incoherent motion MRI in head and neck squamous cell carcinoma'. Together they form a unique fingerprint.

Cite this