Assessment of intestinal permeability using sugar probes: Influence of urinary volume

Francesca Mattioli, Carmen Fucile, Valeria Marini, Luca Isola, Fabio Montanaro, Vincenzo Savarino, Antonietta Martelli

Research output: Contribution to journalArticlepeer-review


Background: As the accuracy of the "Sugar Test" is currently debated, this study was conducted to focus on how urine volumes may impact the test results. Methods: Fifty-five subjects, 23 healthy and 32 with Irritable Bowel Syndrome (IBS), were enrolled. Lactulose and D-mannitol dissolved in water were administered to all the participating subjects; the urine excreted was collected and the total urine volume was measured. The urine samples were analyzed by High Performance Liquid Chromatography (HPLC). The results were expressed as percentage of urine recovery of lactulose and D-mannitol and lactulose/D-mannitol ratio (LMR). Results: All subjects were divided into two groups: subjects with urine volume

Original languageEnglish
Pages (from-to)909-918
Number of pages10
JournalClinical Laboratory
Issue number11-12
Publication statusPublished - 2011


  • High Performance Liquid Chromatography (HPLC)
  • Intestinal permeability
  • Irritable Bowel Syndrome (IBS)
  • Lactulose/D-mannitol ratio (LMR)
  • Sugar test

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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