Assessment of mitoxantrone-induced cardiotoxicity in patients with multiple sclerosis: A tissue doppler echocardiographic analysis

Paolo Pattoneri, Fabiola Sozzi, Giovanna Pelà, Enrico Montanari, Paolo Moruzzi, Alberico Borghetti, Maria Domenica Cappellini

Research output: Contribution to journalArticlepeer-review


Aim: Tissue Doppler echocardiography was investigated for its applicability in detecting subtle myocardial involvement in multiple sclerosis patients receiving a low dose of mitoxantrone. Methods and Results: Twenty Caucasian patients with multiple sclerosis (mean age 43.9 ± 9.3 years, 12 males and 8 females) treated with mitoxantrone (mean cumulative dose 35.4 ± 21.6 mg/m2), were compared to 20 healthy subjects (mean age 45.4 ± 15.3 years, 11 males and 9 females) matched for age and gender. All subjects underwent conventional and Tissue Doppler echocardiography. Patients with heart failure, life-threatening arrhythmias, and other prominent manifestations of heart disease were excluded. No differences were observed in blood pressure, heart rate, and conventional systolic and diastolic echocardiographic parameters. At Tissue Doppler echocardiography, patients with multiple sclerosis showed differences of the systolic mechanic expressed by a significant lower S-wave peak velocity at the lateral site of mitral annulus (11.4 ± 2.5 cm/sec vs. 15.0 ± 4.1 cm/sec, P <0.02). Such S-wave peak velocity significantly correlated with a cumulative dose of mitoxantrone (r = -0.37, P <0.05). Conclusion: Tissue Doppler echocardiography suggests an early involvement of the systolic myocardial function at the low dose of mitoxantrone. Therefore, Tissue Doppler echocardiography may be used as a noninvasive method for monitoring subclinical cardiotoxicity in multiple sclerosis patients receiving mitoxantrone.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
Issue number4
Publication statusPublished - Apr 2009


  • Cardiotoxicity
  • Mitoxantrone
  • Multiple sclerosis
  • Tissue Doppler echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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