Abstract
Aim: Tissue Doppler echocardiography was investigated for its applicability in detecting subtle myocardial involvement in multiple sclerosis patients receiving a low dose of mitoxantrone. Methods and Results: Twenty Caucasian patients with multiple sclerosis (mean age 43.9 ± 9.3 years, 12 males and 8 females) treated with mitoxantrone (mean cumulative dose 35.4 ± 21.6 mg/m2), were compared to 20 healthy subjects (mean age 45.4 ± 15.3 years, 11 males and 9 females) matched for age and gender. All subjects underwent conventional and Tissue Doppler echocardiography. Patients with heart failure, life-threatening arrhythmias, and other prominent manifestations of heart disease were excluded. No differences were observed in blood pressure, heart rate, and conventional systolic and diastolic echocardiographic parameters. At Tissue Doppler echocardiography, patients with multiple sclerosis showed differences of the systolic mechanic expressed by a significant lower S-wave peak velocity at the lateral site of mitral annulus (11.4 ± 2.5 cm/sec vs. 15.0 ± 4.1 cm/sec, P <0.02). Such S-wave peak velocity significantly correlated with a cumulative dose of mitoxantrone (r = -0.37, P <0.05). Conclusion: Tissue Doppler echocardiography suggests an early involvement of the systolic myocardial function at the low dose of mitoxantrone. Therefore, Tissue Doppler echocardiography may be used as a noninvasive method for monitoring subclinical cardiotoxicity in multiple sclerosis patients receiving mitoxantrone.
| Original language | English |
|---|---|
| Pages (from-to) | 397-402 |
| Number of pages | 6 |
| Journal | Echocardiography |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2009 |
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Keywords
- Cardiotoxicity
- Mitoxantrone
- Multiple sclerosis
- Tissue Doppler echocardiography
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
Assessment of mitoxantrone-induced cardiotoxicity in patients with multiple sclerosis : A tissue doppler echocardiographic analysis. / Pattoneri, Paolo; Sozzi, Fabiola; Pelà, Giovanna; Montanari, Enrico; Moruzzi, Paolo; Borghetti, Alberico; Cappellini, Maria Domenica.
In: Echocardiography, Vol. 26, No. 4, 04.2009, p. 397-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of mitoxantrone-induced cardiotoxicity in patients with multiple sclerosis
T2 - A tissue doppler echocardiographic analysis
AU - Pattoneri, Paolo
AU - Sozzi, Fabiola
AU - Pelà, Giovanna
AU - Montanari, Enrico
AU - Moruzzi, Paolo
AU - Borghetti, Alberico
AU - Cappellini, Maria Domenica
PY - 2009/4
Y1 - 2009/4
N2 - Aim: Tissue Doppler echocardiography was investigated for its applicability in detecting subtle myocardial involvement in multiple sclerosis patients receiving a low dose of mitoxantrone. Methods and Results: Twenty Caucasian patients with multiple sclerosis (mean age 43.9 ± 9.3 years, 12 males and 8 females) treated with mitoxantrone (mean cumulative dose 35.4 ± 21.6 mg/m2), were compared to 20 healthy subjects (mean age 45.4 ± 15.3 years, 11 males and 9 females) matched for age and gender. All subjects underwent conventional and Tissue Doppler echocardiography. Patients with heart failure, life-threatening arrhythmias, and other prominent manifestations of heart disease were excluded. No differences were observed in blood pressure, heart rate, and conventional systolic and diastolic echocardiographic parameters. At Tissue Doppler echocardiography, patients with multiple sclerosis showed differences of the systolic mechanic expressed by a significant lower S-wave peak velocity at the lateral site of mitral annulus (11.4 ± 2.5 cm/sec vs. 15.0 ± 4.1 cm/sec, P <0.02). Such S-wave peak velocity significantly correlated with a cumulative dose of mitoxantrone (r = -0.37, P <0.05). Conclusion: Tissue Doppler echocardiography suggests an early involvement of the systolic myocardial function at the low dose of mitoxantrone. Therefore, Tissue Doppler echocardiography may be used as a noninvasive method for monitoring subclinical cardiotoxicity in multiple sclerosis patients receiving mitoxantrone.
AB - Aim: Tissue Doppler echocardiography was investigated for its applicability in detecting subtle myocardial involvement in multiple sclerosis patients receiving a low dose of mitoxantrone. Methods and Results: Twenty Caucasian patients with multiple sclerosis (mean age 43.9 ± 9.3 years, 12 males and 8 females) treated with mitoxantrone (mean cumulative dose 35.4 ± 21.6 mg/m2), were compared to 20 healthy subjects (mean age 45.4 ± 15.3 years, 11 males and 9 females) matched for age and gender. All subjects underwent conventional and Tissue Doppler echocardiography. Patients with heart failure, life-threatening arrhythmias, and other prominent manifestations of heart disease were excluded. No differences were observed in blood pressure, heart rate, and conventional systolic and diastolic echocardiographic parameters. At Tissue Doppler echocardiography, patients with multiple sclerosis showed differences of the systolic mechanic expressed by a significant lower S-wave peak velocity at the lateral site of mitral annulus (11.4 ± 2.5 cm/sec vs. 15.0 ± 4.1 cm/sec, P <0.02). Such S-wave peak velocity significantly correlated with a cumulative dose of mitoxantrone (r = -0.37, P <0.05). Conclusion: Tissue Doppler echocardiography suggests an early involvement of the systolic myocardial function at the low dose of mitoxantrone. Therefore, Tissue Doppler echocardiography may be used as a noninvasive method for monitoring subclinical cardiotoxicity in multiple sclerosis patients receiving mitoxantrone.
KW - Cardiotoxicity
KW - Mitoxantrone
KW - Multiple sclerosis
KW - Tissue Doppler echocardiography
UR - http://www.scopus.com/inward/record.url?scp=63849299043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849299043&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8175.2008.00812.x
DO - 10.1111/j.1540-8175.2008.00812.x
M3 - Article
C2 - 19017314
AN - SCOPUS:63849299043
VL - 26
SP - 397
EP - 402
JO - Echocardiography
JF - Echocardiography
SN - 0742-2822
IS - 4
ER -