Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis

Paola Tortorella, Maria A. Rocca, Bruno Colombo, Pietro Annovazzi, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG). Purpose: To evaluate whether and at which frequency these structures are involved by MRI-detectable structural abnormalities in migraineurs and to investigate the pathogenic role of these abnormalities by assessing their frequency and extent in patients with multiple sclerosis (MS) and migraine. Methods: On brain dual-echo scans obtained from 58 migraineurs (40 without and 18 with aura), 37 MS patients with migraine without aura and 42 MS patients without migraine, the presence of hyperintense lesions involving the brainstem structures was recorded. A test of heterogeneity between groups was used to compare the presence of lesions among patient groups. Results: Lesions of RN, SN and PAG were found in all patient groups, with frequency from 57.5% to 86.5%. Significant between-group differences for all these regions were found. No difference was found between migraine patients with and without aura. Compared with MS patients without migraine, MS patients with migraine had more significant involvement of the SN (p = 0.02) and RN (p <0.0001). Compared with migraine patients, MS patients with migraine had more significant involvement of the SN and PAG (p ranging from 0.009 to 0.02). Conclusions: T2-visible lesions in the brainstem are frequent in patients with migraine, but do not seem to be associated with the presence of aura. Demyelinating lesions in the RN, SN and PAG might be among the factors responsible for the presence of migraine in patients with MS.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalJournal of the Neurological Sciences
Volume244
Issue number1-2
DOIs
Publication statusPublished - May 15 2006

Fingerprint

Migraine Disorders
Brain Stem
Multiple Sclerosis
Red Nucleus
Substantia Nigra
Periaqueductal Gray
Migraine without Aura
Epilepsy
Migraine with Aura

Keywords

  • Brainstem
  • Magnetic resonance imaging
  • Migraine
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis. / Tortorella, Paola; Rocca, Maria A.; Colombo, Bruno; Annovazzi, Pietro; Comi, Giancarlo; Filippi, Massimo.

In: Journal of the Neurological Sciences, Vol. 244, No. 1-2, 15.05.2006, p. 137-141.

Research output: Contribution to journalArticle

@article{e16e868b19ad4cafa498ac51448409fc,
title = "Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis",
abstract = "Background: In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG). Purpose: To evaluate whether and at which frequency these structures are involved by MRI-detectable structural abnormalities in migraineurs and to investigate the pathogenic role of these abnormalities by assessing their frequency and extent in patients with multiple sclerosis (MS) and migraine. Methods: On brain dual-echo scans obtained from 58 migraineurs (40 without and 18 with aura), 37 MS patients with migraine without aura and 42 MS patients without migraine, the presence of hyperintense lesions involving the brainstem structures was recorded. A test of heterogeneity between groups was used to compare the presence of lesions among patient groups. Results: Lesions of RN, SN and PAG were found in all patient groups, with frequency from 57.5{\%} to 86.5{\%}. Significant between-group differences for all these regions were found. No difference was found between migraine patients with and without aura. Compared with MS patients without migraine, MS patients with migraine had more significant involvement of the SN (p = 0.02) and RN (p <0.0001). Compared with migraine patients, MS patients with migraine had more significant involvement of the SN and PAG (p ranging from 0.009 to 0.02). Conclusions: T2-visible lesions in the brainstem are frequent in patients with migraine, but do not seem to be associated with the presence of aura. Demyelinating lesions in the RN, SN and PAG might be among the factors responsible for the presence of migraine in patients with MS.",
keywords = "Brainstem, Magnetic resonance imaging, Migraine, Multiple sclerosis",
author = "Paola Tortorella and Rocca, {Maria A.} and Bruno Colombo and Pietro Annovazzi and Giancarlo Comi and Massimo Filippi",
year = "2006",
month = "5",
day = "15",
doi = "10.1016/j.jns.2006.01.015",
language = "English",
volume = "244",
pages = "137--141",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis

AU - Tortorella, Paola

AU - Rocca, Maria A.

AU - Colombo, Bruno

AU - Annovazzi, Pietro

AU - Comi, Giancarlo

AU - Filippi, Massimo

PY - 2006/5/15

Y1 - 2006/5/15

N2 - Background: In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG). Purpose: To evaluate whether and at which frequency these structures are involved by MRI-detectable structural abnormalities in migraineurs and to investigate the pathogenic role of these abnormalities by assessing their frequency and extent in patients with multiple sclerosis (MS) and migraine. Methods: On brain dual-echo scans obtained from 58 migraineurs (40 without and 18 with aura), 37 MS patients with migraine without aura and 42 MS patients without migraine, the presence of hyperintense lesions involving the brainstem structures was recorded. A test of heterogeneity between groups was used to compare the presence of lesions among patient groups. Results: Lesions of RN, SN and PAG were found in all patient groups, with frequency from 57.5% to 86.5%. Significant between-group differences for all these regions were found. No difference was found between migraine patients with and without aura. Compared with MS patients without migraine, MS patients with migraine had more significant involvement of the SN (p = 0.02) and RN (p <0.0001). Compared with migraine patients, MS patients with migraine had more significant involvement of the SN and PAG (p ranging from 0.009 to 0.02). Conclusions: T2-visible lesions in the brainstem are frequent in patients with migraine, but do not seem to be associated with the presence of aura. Demyelinating lesions in the RN, SN and PAG might be among the factors responsible for the presence of migraine in patients with MS.

AB - Background: In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG). Purpose: To evaluate whether and at which frequency these structures are involved by MRI-detectable structural abnormalities in migraineurs and to investigate the pathogenic role of these abnormalities by assessing their frequency and extent in patients with multiple sclerosis (MS) and migraine. Methods: On brain dual-echo scans obtained from 58 migraineurs (40 without and 18 with aura), 37 MS patients with migraine without aura and 42 MS patients without migraine, the presence of hyperintense lesions involving the brainstem structures was recorded. A test of heterogeneity between groups was used to compare the presence of lesions among patient groups. Results: Lesions of RN, SN and PAG were found in all patient groups, with frequency from 57.5% to 86.5%. Significant between-group differences for all these regions were found. No difference was found between migraine patients with and without aura. Compared with MS patients without migraine, MS patients with migraine had more significant involvement of the SN (p = 0.02) and RN (p <0.0001). Compared with migraine patients, MS patients with migraine had more significant involvement of the SN and PAG (p ranging from 0.009 to 0.02). Conclusions: T2-visible lesions in the brainstem are frequent in patients with migraine, but do not seem to be associated with the presence of aura. Demyelinating lesions in the RN, SN and PAG might be among the factors responsible for the presence of migraine in patients with MS.

KW - Brainstem

KW - Magnetic resonance imaging

KW - Migraine

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=33646095189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646095189&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2006.01.015

DO - 10.1016/j.jns.2006.01.015

M3 - Article

VL - 244

SP - 137

EP - 141

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -