Assessment of myocardial adrenergic innervation with a solid-state dedicated cardiac cadmium-zinc-telluride camera: First clinical experience

Alessia Gimelli, Riccardo Liga, Assuero Giorgetti, Dario Genovesi, Paolo Marzullo

Research output: Contribution to journalArticle

Abstract

AimsTo investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera.MethodsTwenty-eight patients with or without ischaemic heart disease underwent 123I-metaiodobenzylguanidine (MIBG) planar scintigraphic and CZT early and delayed evaluations followed by 99mTc-tetrofosmin rest gated CZT with a single-day protocol. The heart-to-mediastinum ratio and the washout rate were computed from planar 123I-MIBG images. The summed 123I-MIBG defect scores (SS-MIBG) were semi-quantitatively assessed from CZT images. The summed rest score (SRS), summed motion score (SMS), and summed thickening score (STS) were quantitated from 99mTc-tetrofosmin images.ResultsSixteen patients showed a depressed left ventricular systolic function [ejection fraction (EF)

Original languageEnglish
Pages (from-to)575-585
Number of pages11
JournalEuropean Heart Journal Cardiovascular Imaging
Volume15
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Cardiac innervation
  • CZT camera
  • Heart-to-mediastinum ratio

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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