Assessment of Myocardial Contractility by SonR Sensor in Patients Undergoing Cardiac Resynchronization Therapy

Stefania Sacchi, Alessandro Paoletti Perini, Paola Attanà, Gino Grifoni, Marco Chiostri, Giuseppe Ricciardi, Paolo Pieragnoli, Luigi Padeletti

Research output: Contribution to journalArticle

Abstract

Background: SonR sensor signal correlates well with myocardial contractility expressed in terms of left ventricular (LV) dP/dt max. The aim of our study was to evaluate the changes in myocardial contractility during isometric effort in heart failure patients undergoing cardiac resynchronization therapy (CRT) with right atrial SonR sensor. Methods: Thirty-one patients (19 men, 65 ± 7 years, LV ejection fraction [LVEF] 28% ± 5%, in sinus rhythm) were implanted with a CRT-defibrillator (CRT-D) device equipped with SonR sensor, which was programmed in VVI mode at 40 beats/min. Twenty-four hours after implantation, each patient underwent a noninvasive hemodynamic evaluation at rest and during isometric effort, including: (1) measurement of beat-to-beat endocavitary SonR signal; (2) echocardiographic assessment; and (3) continuous measurement of blood pressure with Nexfin method (BMEYE, Amsterdam, the Netherlands). The following contractility parameters were considered: (1) mean value of beat-to-beat SonR signal; (2) mean value of LV dP/dt by Nexfin system; and (3) fractional shortening (FS) by echocardiography. Results: At the third minute of the isometric effort, mean value of SonR signal significantly increased from baseline (P <0.001). Similarly, mean value of both LV dP/dt by Nexfin and FS significantly increased compared to the resting condition (P <0.001; P <0.001). While in 27 (88%) patients SonR signal increased at the third minute of the isometric effort, in four (12%) patients SonR signal decreased. In these patients, both LV dP/dt by Nexfin and FS consensually decreased. Conclusions: In CRT patients, SonR sensor is able to detect changes in myocardial contractility in a consensual way like noninvasive methods such as Nexfin system and echocardiography.

Original languageEnglish
JournalPACE - Pacing and Clinical Electrophysiology
DOIs
Publication statusAccepted/In press - 2016

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Cardiac Resynchronization Therapy
Echocardiography
Cardiac Resynchronization Therapy Devices
Defibrillators
Netherlands
Stroke Volume
Heart Failure
Hemodynamics
Blood Pressure

Keywords

  • Cardiac resynchronization therapy
  • Heart failure
  • Myocardial contractility
  • Right atrial SonR sensor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Assessment of Myocardial Contractility by SonR Sensor in Patients Undergoing Cardiac Resynchronization Therapy. / Sacchi, Stefania; Perini, Alessandro Paoletti; Attanà, Paola; Grifoni, Gino; Chiostri, Marco; Ricciardi, Giuseppe; Pieragnoli, Paolo; Padeletti, Luigi.

In: PACE - Pacing and Clinical Electrophysiology, 2016.

Research output: Contribution to journalArticle

Sacchi, Stefania ; Perini, Alessandro Paoletti ; Attanà, Paola ; Grifoni, Gino ; Chiostri, Marco ; Ricciardi, Giuseppe ; Pieragnoli, Paolo ; Padeletti, Luigi. / Assessment of Myocardial Contractility by SonR Sensor in Patients Undergoing Cardiac Resynchronization Therapy. In: PACE - Pacing and Clinical Electrophysiology. 2016.
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abstract = "Background: SonR sensor signal correlates well with myocardial contractility expressed in terms of left ventricular (LV) dP/dt max. The aim of our study was to evaluate the changes in myocardial contractility during isometric effort in heart failure patients undergoing cardiac resynchronization therapy (CRT) with right atrial SonR sensor. Methods: Thirty-one patients (19 men, 65 ± 7 years, LV ejection fraction [LVEF] 28{\%} ± 5{\%}, in sinus rhythm) were implanted with a CRT-defibrillator (CRT-D) device equipped with SonR sensor, which was programmed in VVI mode at 40 beats/min. Twenty-four hours after implantation, each patient underwent a noninvasive hemodynamic evaluation at rest and during isometric effort, including: (1) measurement of beat-to-beat endocavitary SonR signal; (2) echocardiographic assessment; and (3) continuous measurement of blood pressure with Nexfin method (BMEYE, Amsterdam, the Netherlands). The following contractility parameters were considered: (1) mean value of beat-to-beat SonR signal; (2) mean value of LV dP/dt by Nexfin system; and (3) fractional shortening (FS) by echocardiography. Results: At the third minute of the isometric effort, mean value of SonR signal significantly increased from baseline (P <0.001). Similarly, mean value of both LV dP/dt by Nexfin and FS significantly increased compared to the resting condition (P <0.001; P <0.001). While in 27 (88{\%}) patients SonR signal increased at the third minute of the isometric effort, in four (12{\%}) patients SonR signal decreased. In these patients, both LV dP/dt by Nexfin and FS consensually decreased. Conclusions: In CRT patients, SonR sensor is able to detect changes in myocardial contractility in a consensual way like noninvasive methods such as Nexfin system and echocardiography.",
keywords = "Cardiac resynchronization therapy, Heart failure, Myocardial contractility, Right atrial SonR sensor",
author = "Stefania Sacchi and Perini, {Alessandro Paoletti} and Paola Attan{\`a} and Gino Grifoni and Marco Chiostri and Giuseppe Ricciardi and Paolo Pieragnoli and Luigi Padeletti",
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T1 - Assessment of Myocardial Contractility by SonR Sensor in Patients Undergoing Cardiac Resynchronization Therapy

AU - Sacchi, Stefania

AU - Perini, Alessandro Paoletti

AU - Attanà, Paola

AU - Grifoni, Gino

AU - Chiostri, Marco

AU - Ricciardi, Giuseppe

AU - Pieragnoli, Paolo

AU - Padeletti, Luigi

PY - 2016

Y1 - 2016

N2 - Background: SonR sensor signal correlates well with myocardial contractility expressed in terms of left ventricular (LV) dP/dt max. The aim of our study was to evaluate the changes in myocardial contractility during isometric effort in heart failure patients undergoing cardiac resynchronization therapy (CRT) with right atrial SonR sensor. Methods: Thirty-one patients (19 men, 65 ± 7 years, LV ejection fraction [LVEF] 28% ± 5%, in sinus rhythm) were implanted with a CRT-defibrillator (CRT-D) device equipped with SonR sensor, which was programmed in VVI mode at 40 beats/min. Twenty-four hours after implantation, each patient underwent a noninvasive hemodynamic evaluation at rest and during isometric effort, including: (1) measurement of beat-to-beat endocavitary SonR signal; (2) echocardiographic assessment; and (3) continuous measurement of blood pressure with Nexfin method (BMEYE, Amsterdam, the Netherlands). The following contractility parameters were considered: (1) mean value of beat-to-beat SonR signal; (2) mean value of LV dP/dt by Nexfin system; and (3) fractional shortening (FS) by echocardiography. Results: At the third minute of the isometric effort, mean value of SonR signal significantly increased from baseline (P <0.001). Similarly, mean value of both LV dP/dt by Nexfin and FS significantly increased compared to the resting condition (P <0.001; P <0.001). While in 27 (88%) patients SonR signal increased at the third minute of the isometric effort, in four (12%) patients SonR signal decreased. In these patients, both LV dP/dt by Nexfin and FS consensually decreased. Conclusions: In CRT patients, SonR sensor is able to detect changes in myocardial contractility in a consensual way like noninvasive methods such as Nexfin system and echocardiography.

AB - Background: SonR sensor signal correlates well with myocardial contractility expressed in terms of left ventricular (LV) dP/dt max. The aim of our study was to evaluate the changes in myocardial contractility during isometric effort in heart failure patients undergoing cardiac resynchronization therapy (CRT) with right atrial SonR sensor. Methods: Thirty-one patients (19 men, 65 ± 7 years, LV ejection fraction [LVEF] 28% ± 5%, in sinus rhythm) were implanted with a CRT-defibrillator (CRT-D) device equipped with SonR sensor, which was programmed in VVI mode at 40 beats/min. Twenty-four hours after implantation, each patient underwent a noninvasive hemodynamic evaluation at rest and during isometric effort, including: (1) measurement of beat-to-beat endocavitary SonR signal; (2) echocardiographic assessment; and (3) continuous measurement of blood pressure with Nexfin method (BMEYE, Amsterdam, the Netherlands). The following contractility parameters were considered: (1) mean value of beat-to-beat SonR signal; (2) mean value of LV dP/dt by Nexfin system; and (3) fractional shortening (FS) by echocardiography. Results: At the third minute of the isometric effort, mean value of SonR signal significantly increased from baseline (P <0.001). Similarly, mean value of both LV dP/dt by Nexfin and FS significantly increased compared to the resting condition (P <0.001; P <0.001). While in 27 (88%) patients SonR signal increased at the third minute of the isometric effort, in four (12%) patients SonR signal decreased. In these patients, both LV dP/dt by Nexfin and FS consensually decreased. Conclusions: In CRT patients, SonR sensor is able to detect changes in myocardial contractility in a consensual way like noninvasive methods such as Nexfin system and echocardiography.

KW - Cardiac resynchronization therapy

KW - Heart failure

KW - Myocardial contractility

KW - Right atrial SonR sensor

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