Assessment of myocardial perfusion and viability with technetium-99m methoxyisobutylisonitrile and thallium-201 rest redistribution in chronic coronary artery disease

C. Rossetti, C. Landoni, G. Lucignani, G. Huang, A. L. Bartorelli, M. D. Guazzi, A. Margonato, S. Chierchia, L. Galli, A. Savi, F. Fazio

Research output: Contribution to journalArticle

Abstract

We compare thallium-201 rest redistribution and fluorine-18 fluorodeoxyglucose ([18F]FDG) for the assessment of myocardial viability within technetium-99m methoxyisobutylisonitrile (MIBI) perfusion defects in 27 patients with chronic stable coronary artery disease. The following studies were performed: (1) stress99mTc-MIBI, (2) rest99mTc-MIBI, (3)201T1 rest-redistribution single-photon emission tomography, (4) [18F]FDG positron emission tomography. The left ventricle was devided into 11 segments on matched tomographic images. The segment with the highest activity at stress was taken as the reference (activity=100%). Perfusion defects at99mTc-MIBI rest were classified as severe (activity18F]FDG and rest-redistributed201Tl were recognized as significant if they exceeded 50% of that in the reference segment. Among the 33 segments with severe99mTc-MIBI rest perfusion defects, 21 had significant [18F]FDG and 10 significant rest-redistributed201Tl uptake. As regards the 37 segments with moderate defects, [18F]FDG was present in 29 and201Tl in 31, while of the 134 segments with mild defects, 128 showed [18F]FDG uptake, and 131,201Tl uptake. In conclusion, there is an inverse relationship between the severity of99mTc-MIBI perfusion defects and the uptake of rest-redistributed201Tl and [18F]FDG. Both tracers are adequate markers of viability in mild and moderate defects; in severe defects201Tl might underestimate the presence of viability as assessed by [18F]FDG.

Original languageEnglish
Pages (from-to)1306-1312
Number of pages7
JournalEuropean Journal Of Nuclear Medicine
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1995

Keywords

  • Myocardial perfusion
  • Myocardial viability
  • Positron emission tomography
  • Single-photon emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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