Assessment of nociceptive system in vegetative and minimally conscious state by using laser evoked potentials

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Primary objective: The aim of this study is to assess if laser evoked potentials (LEPs) examination should be considered as an objective evidence of potential or residual pain perception capacity in vegetative (VS) and minimally conscious state (MCS) patients and if it could be a feasible methodology in order to differentiate these two clinical entities.Research design: This is a cross-sectional observational study focusing on the role of LEP examination, which is an easy and objective neurophysiological approach of the nociceptive system.Methods and procedures: Thirteen VS and 10 MCS patients were enrolled. All subjects were evaluated clinically by using validated behavioural scales and underwent to upper and lower limbs LEP recording.Main outcomes and results: Intra-group LEPs analysis in VS patients highlighted significant differences for N2P2 latency (p = 0.036) and amplitude (p = 0.018). Inter-group LEPs analysis showed significant differences in post-anoxic condition for N2P2 latency (p = 0.034), amplitude (p = 0.034) and a trend in N2P2 latency in brain trauma (p = 0.07). Interestingly, correlation analysis showed a significant relationship between N2P2 amplitude and Coma Recovery Scale-Revised scoring in the post-traumatic VS (r = 0.823, p = 0.044).Conclusions: The findings lead to detection of potential markers of conscious pain perception in patients with DOC, with important impact on therapeutic and rehabilitative management, and provide new information that may allow a better differential diagnosis.

Original languageEnglish
Pages (from-to)1467-1474
Number of pages8
JournalBrain Injury
Volume29
Issue number12
DOIs
Publication statusPublished - Oct 15 2015

Fingerprint

Persistent Vegetative State
Pain Perception
Coma
Observational Studies
Lower Extremity
Differential Diagnosis
Research Design
Cross-Sectional Studies
Laser-Evoked Potentials
Evoked Potentials
Laser
Conscious
Latency

Keywords

  • Laser evoked potentials
  • minimally conscious state
  • outcome evaluation
  • pain
  • vegetative state

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Assessment of nociceptive system in vegetative and minimally conscious state by using laser evoked potentials. / De Salvo, S.; Naro, A.; Bonanno, L.; Russo, M.; Muscarà, N.; Bramanti, P.; Marino, S.

In: Brain Injury, Vol. 29, No. 12, 15.10.2015, p. 1467-1474.

Research output: Contribution to journalArticle

@article{48131a3a70074a93b3fdc956c7a86c90,
title = "Assessment of nociceptive system in vegetative and minimally conscious state by using laser evoked potentials",
abstract = "Primary objective: The aim of this study is to assess if laser evoked potentials (LEPs) examination should be considered as an objective evidence of potential or residual pain perception capacity in vegetative (VS) and minimally conscious state (MCS) patients and if it could be a feasible methodology in order to differentiate these two clinical entities.Research design: This is a cross-sectional observational study focusing on the role of LEP examination, which is an easy and objective neurophysiological approach of the nociceptive system.Methods and procedures: Thirteen VS and 10 MCS patients were enrolled. All subjects were evaluated clinically by using validated behavioural scales and underwent to upper and lower limbs LEP recording.Main outcomes and results: Intra-group LEPs analysis in VS patients highlighted significant differences for N2P2 latency (p = 0.036) and amplitude (p = 0.018). Inter-group LEPs analysis showed significant differences in post-anoxic condition for N2P2 latency (p = 0.034), amplitude (p = 0.034) and a trend in N2P2 latency in brain trauma (p = 0.07). Interestingly, correlation analysis showed a significant relationship between N2P2 amplitude and Coma Recovery Scale-Revised scoring in the post-traumatic VS (r = 0.823, p = 0.044).Conclusions: The findings lead to detection of potential markers of conscious pain perception in patients with DOC, with important impact on therapeutic and rehabilitative management, and provide new information that may allow a better differential diagnosis.",
keywords = "Laser evoked potentials, minimally conscious state, outcome evaluation, pain, vegetative state",
author = "{De Salvo}, S. and A. Naro and L. Bonanno and M. Russo and N. Muscar{\`a} and P. Bramanti and S. Marino",
year = "2015",
month = "10",
day = "15",
doi = "10.3109/02699052.2015.1071430",
language = "English",
volume = "29",
pages = "1467--1474",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Assessment of nociceptive system in vegetative and minimally conscious state by using laser evoked potentials

AU - De Salvo, S.

AU - Naro, A.

AU - Bonanno, L.

AU - Russo, M.

AU - Muscarà, N.

AU - Bramanti, P.

AU - Marino, S.

PY - 2015/10/15

Y1 - 2015/10/15

N2 - Primary objective: The aim of this study is to assess if laser evoked potentials (LEPs) examination should be considered as an objective evidence of potential or residual pain perception capacity in vegetative (VS) and minimally conscious state (MCS) patients and if it could be a feasible methodology in order to differentiate these two clinical entities.Research design: This is a cross-sectional observational study focusing on the role of LEP examination, which is an easy and objective neurophysiological approach of the nociceptive system.Methods and procedures: Thirteen VS and 10 MCS patients were enrolled. All subjects were evaluated clinically by using validated behavioural scales and underwent to upper and lower limbs LEP recording.Main outcomes and results: Intra-group LEPs analysis in VS patients highlighted significant differences for N2P2 latency (p = 0.036) and amplitude (p = 0.018). Inter-group LEPs analysis showed significant differences in post-anoxic condition for N2P2 latency (p = 0.034), amplitude (p = 0.034) and a trend in N2P2 latency in brain trauma (p = 0.07). Interestingly, correlation analysis showed a significant relationship between N2P2 amplitude and Coma Recovery Scale-Revised scoring in the post-traumatic VS (r = 0.823, p = 0.044).Conclusions: The findings lead to detection of potential markers of conscious pain perception in patients with DOC, with important impact on therapeutic and rehabilitative management, and provide new information that may allow a better differential diagnosis.

AB - Primary objective: The aim of this study is to assess if laser evoked potentials (LEPs) examination should be considered as an objective evidence of potential or residual pain perception capacity in vegetative (VS) and minimally conscious state (MCS) patients and if it could be a feasible methodology in order to differentiate these two clinical entities.Research design: This is a cross-sectional observational study focusing on the role of LEP examination, which is an easy and objective neurophysiological approach of the nociceptive system.Methods and procedures: Thirteen VS and 10 MCS patients were enrolled. All subjects were evaluated clinically by using validated behavioural scales and underwent to upper and lower limbs LEP recording.Main outcomes and results: Intra-group LEPs analysis in VS patients highlighted significant differences for N2P2 latency (p = 0.036) and amplitude (p = 0.018). Inter-group LEPs analysis showed significant differences in post-anoxic condition for N2P2 latency (p = 0.034), amplitude (p = 0.034) and a trend in N2P2 latency in brain trauma (p = 0.07). Interestingly, correlation analysis showed a significant relationship between N2P2 amplitude and Coma Recovery Scale-Revised scoring in the post-traumatic VS (r = 0.823, p = 0.044).Conclusions: The findings lead to detection of potential markers of conscious pain perception in patients with DOC, with important impact on therapeutic and rehabilitative management, and provide new information that may allow a better differential diagnosis.

KW - Laser evoked potentials

KW - minimally conscious state

KW - outcome evaluation

KW - pain

KW - vegetative state

UR - http://www.scopus.com/inward/record.url?scp=84947037275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947037275&partnerID=8YFLogxK

U2 - 10.3109/02699052.2015.1071430

DO - 10.3109/02699052.2015.1071430

M3 - Article

C2 - 26362906

AN - SCOPUS:84947037275

VL - 29

SP - 1467

EP - 1474

JO - Brain Injury

JF - Brain Injury

SN - 0269-9052

IS - 12

ER -