Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: A diffusion-tensor magnetic resonance imaging study

Marco Rovaris, Marco Bozzali, Giuseppe Iannucci, Angelo Ghezzi, Domenico Caputo, Enrico Montanari, Antonio Bertolotto, Roberto Bergamaschi, Ruggero Capra, Giovanni Luigi Mancardi, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Background: Diffusion-tensor magnetic resonance imaging is sensitive to the more destructive aspects of multiple sclerosis (MS) evolution occurring outside and within T2-visible lesions and, as a consequence, holds promise for providing a more complete picture of primary progressive (PP) MS-related tissue damage than conventional magnetic resonance imaging. Objective: To improve our understanding of PPMS by assessing the extent of occult pathological features in the normal-appearing white and gray matter of the brain using diffusion-tensor magnetic resonance imaging. Methods: Ninety-six patients with PPMS, 47 patients with secondary progressive (SP) MS, and 44 healthy control subjects were studied. T2-hyperintense and T1-hypointense lesion volumes were calculated, and the volume of the whole brain tissue was measured. Diffusion-tensor magnetic resonance imaging scans were postprocessed and analyzed to obtain the mean diffusivity and fractional anisotropy histograms from the brain and from the normal-appearing white and gray matter in isolation. Results: The mean T2-hyperintense and T1-hypointense lesion volumes were lower in patients with PPMS than in patients with SPMS, while the mean absolute brain volumes were similar in the 2 groups. The average lesion diffusivity was significantly higher in patients with SPMS than in patients with PPMS (P

Original languageEnglish
Pages (from-to)1406-1412
Number of pages7
JournalArchives of Neurology
Volume59
Issue number9
DOIs
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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