VALUTAZIONE DELLA TOSSICITA OCULARE E STUDIO DELLE VIE OTTICHE. SU 13 PAZIENTI AFFETTI DA GLIOMA CEREBRALE MALIGNO SOTTOPOSTI A CHEMIOTERAPIA INTRAARTERIOSA CON CARBOPLATINO ED ETOPOSIDE

Translated title of the contribution: Assessment of ocular toxicity and investigation of the optic pathways. 13 Patients with malignant brain gliomas following intra-arterial chemotherapy with carboplatin and etoposide

M. G. Egitto, C. Uggetti, F. Zappoli, L. Sibilla, A. Martelli, J. Karau, R. Ceccuzzi

Research output: Contribution to journalArticle

Abstract

Early trials using selective intra-arterial drug administration for the chemotherapy of malignant brain gliomas caused unacceptable levels of neurological toxicity, with particular damage to the optic nerves. In vitro studies combining carboplatin, derived from cisplatin, with etoposide, a semi-synthetic derivative of podophyllotoxin, showed an elevated cytotoxicity to glial cells and synergy in reducing the intrinsic drug-resistance of glial tumour cells. There is considerable evidence of fewer systemic and neurological side effects of this combination given by selective intra-arterial route. This paper assesses specific damage to the optic nerves and central optic pathways caused by this chemotherapy. Thirteen patients with malignant brain glioma who received at least four cycles of subophthalmic intraarterial chemotherapy underwent full objective and subjective eye tests (visual field examination, ocular tonometry, examination of the fundus and intrinsic and extrinsic ocular motility; assessment of visual acuity, sensitivity to contrast and colour sense). All patients underwent MR imaging with paramagnetic contrast medium to disclose involvement of the optic pathways which would account for visual changes detected in the eye tests. Our findings show that carboplatin associated with etoposide do not affect the central and peripheral optic pathways. Chemotherapy can be administered by subophthalmic injection into the carotid arteries to perfuse large areas of brain tissue and enhance the possibility of the drugs reaching the infiltrating tumour cells at some distance from the tumour mass.

Original languageItalian
Pages (from-to)493-496
Number of pages4
JournalRivista di Neuroradiologia
Volume8
Issue number4
Publication statusPublished - 1995

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Carboplatin
Etoposide
Glioma
Drug Therapy
Brain
Optic Nerve
Ocular Tonometry
Podophyllotoxin
Visual Field Tests
Contrast Sensitivity
Carotid Arteries
Drug Resistance
Neuroglia
Pharmaceutical Preparations
Contrast Media
Cisplatin
Visual Acuity
Neoplasms
Color
Injections

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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title = "VALUTAZIONE DELLA TOSSICITA OCULARE E STUDIO DELLE VIE OTTICHE. SU 13 PAZIENTI AFFETTI DA GLIOMA CEREBRALE MALIGNO SOTTOPOSTI A CHEMIOTERAPIA INTRAARTERIOSA CON CARBOPLATINO ED ETOPOSIDE",
abstract = "Early trials using selective intra-arterial drug administration for the chemotherapy of malignant brain gliomas caused unacceptable levels of neurological toxicity, with particular damage to the optic nerves. In vitro studies combining carboplatin, derived from cisplatin, with etoposide, a semi-synthetic derivative of podophyllotoxin, showed an elevated cytotoxicity to glial cells and synergy in reducing the intrinsic drug-resistance of glial tumour cells. There is considerable evidence of fewer systemic and neurological side effects of this combination given by selective intra-arterial route. This paper assesses specific damage to the optic nerves and central optic pathways caused by this chemotherapy. Thirteen patients with malignant brain glioma who received at least four cycles of subophthalmic intraarterial chemotherapy underwent full objective and subjective eye tests (visual field examination, ocular tonometry, examination of the fundus and intrinsic and extrinsic ocular motility; assessment of visual acuity, sensitivity to contrast and colour sense). All patients underwent MR imaging with paramagnetic contrast medium to disclose involvement of the optic pathways which would account for visual changes detected in the eye tests. Our findings show that carboplatin associated with etoposide do not affect the central and peripheral optic pathways. Chemotherapy can be administered by subophthalmic injection into the carotid arteries to perfuse large areas of brain tissue and enhance the possibility of the drugs reaching the infiltrating tumour cells at some distance from the tumour mass.",
keywords = "brain gliomas, carboplatin, etoposide, intra-arterial chemotherapy, ocular toxicity, visual field",
author = "Egitto, {M. G.} and C. Uggetti and F. Zappoli and L. Sibilla and A. Martelli and J. Karau and R. Ceccuzzi",
year = "1995",
language = "Italian",
volume = "8",
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journal = "Rivista di Neuroradiologia",
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T1 - VALUTAZIONE DELLA TOSSICITA OCULARE E STUDIO DELLE VIE OTTICHE. SU 13 PAZIENTI AFFETTI DA GLIOMA CEREBRALE MALIGNO SOTTOPOSTI A CHEMIOTERAPIA INTRAARTERIOSA CON CARBOPLATINO ED ETOPOSIDE

AU - Egitto, M. G.

AU - Uggetti, C.

AU - Zappoli, F.

AU - Sibilla, L.

AU - Martelli, A.

AU - Karau, J.

AU - Ceccuzzi, R.

PY - 1995

Y1 - 1995

N2 - Early trials using selective intra-arterial drug administration for the chemotherapy of malignant brain gliomas caused unacceptable levels of neurological toxicity, with particular damage to the optic nerves. In vitro studies combining carboplatin, derived from cisplatin, with etoposide, a semi-synthetic derivative of podophyllotoxin, showed an elevated cytotoxicity to glial cells and synergy in reducing the intrinsic drug-resistance of glial tumour cells. There is considerable evidence of fewer systemic and neurological side effects of this combination given by selective intra-arterial route. This paper assesses specific damage to the optic nerves and central optic pathways caused by this chemotherapy. Thirteen patients with malignant brain glioma who received at least four cycles of subophthalmic intraarterial chemotherapy underwent full objective and subjective eye tests (visual field examination, ocular tonometry, examination of the fundus and intrinsic and extrinsic ocular motility; assessment of visual acuity, sensitivity to contrast and colour sense). All patients underwent MR imaging with paramagnetic contrast medium to disclose involvement of the optic pathways which would account for visual changes detected in the eye tests. Our findings show that carboplatin associated with etoposide do not affect the central and peripheral optic pathways. Chemotherapy can be administered by subophthalmic injection into the carotid arteries to perfuse large areas of brain tissue and enhance the possibility of the drugs reaching the infiltrating tumour cells at some distance from the tumour mass.

AB - Early trials using selective intra-arterial drug administration for the chemotherapy of malignant brain gliomas caused unacceptable levels of neurological toxicity, with particular damage to the optic nerves. In vitro studies combining carboplatin, derived from cisplatin, with etoposide, a semi-synthetic derivative of podophyllotoxin, showed an elevated cytotoxicity to glial cells and synergy in reducing the intrinsic drug-resistance of glial tumour cells. There is considerable evidence of fewer systemic and neurological side effects of this combination given by selective intra-arterial route. This paper assesses specific damage to the optic nerves and central optic pathways caused by this chemotherapy. Thirteen patients with malignant brain glioma who received at least four cycles of subophthalmic intraarterial chemotherapy underwent full objective and subjective eye tests (visual field examination, ocular tonometry, examination of the fundus and intrinsic and extrinsic ocular motility; assessment of visual acuity, sensitivity to contrast and colour sense). All patients underwent MR imaging with paramagnetic contrast medium to disclose involvement of the optic pathways which would account for visual changes detected in the eye tests. Our findings show that carboplatin associated with etoposide do not affect the central and peripheral optic pathways. Chemotherapy can be administered by subophthalmic injection into the carotid arteries to perfuse large areas of brain tissue and enhance the possibility of the drugs reaching the infiltrating tumour cells at some distance from the tumour mass.

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KW - etoposide

KW - intra-arterial chemotherapy

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KW - visual field

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