Assessment of oxidative stress in coronary artery bypass surgery

Comparison between the global index OXY-SCORE and individual biomarkers

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalBiomarkers
Volume14
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Oxidative stress
Biomarkers
Malondialdehyde
Coronary Artery Bypass
Surgery
Oxidative Stress
Isoprostanes
Tocopherols
Glutathione Disulfide
Cardiopulmonary Bypass
ROC Curve
Area Under Curve
Glutathione
Antioxidants
Pumps
Plasmas

Keywords

  • Coronary artery bypass graft
  • Glutathione
  • Malondialdehyde
  • Oxidative stress global index

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

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T1 - Assessment of oxidative stress in coronary artery bypass surgery

T2 - Comparison between the global index OXY-SCORE and individual biomarkers

AU - Veglia, Fabrizio

AU - Werba, José P.

AU - Tremoli, Elena

AU - Squellerio, Isabella

AU - Sisillo, Erminio

AU - Parolari, Alessandro

AU - Minardi, Fabiana

AU - Cavalca, Viviana

PY - 2009

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KW - Glutathione

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KW - Oxidative stress global index

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