Abstract
The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
| Original language | English |
|---|---|
| Pages (from-to) | 465-472 |
| Number of pages | 8 |
| Journal | Biomarkers |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Coronary artery bypass graft
- Glutathione
- Malondialdehyde
- Oxidative stress global index
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
Cite this
Assessment of oxidative stress in coronary artery bypass surgery : Comparison between the global index OXY-SCORE and individual biomarkers. / Veglia, Fabrizio; Werba, José P.; Tremoli, Elena; Squellerio, Isabella; Sisillo, Erminio; Parolari, Alessandro; Minardi, Fabiana; Cavalca, Viviana.
In: Biomarkers, Vol. 14, No. 7, 2009, p. 465-472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of oxidative stress in coronary artery bypass surgery
T2 - Comparison between the global index OXY-SCORE and individual biomarkers
AU - Veglia, Fabrizio
AU - Werba, José P.
AU - Tremoli, Elena
AU - Squellerio, Isabella
AU - Sisillo, Erminio
AU - Parolari, Alessandro
AU - Minardi, Fabiana
AU - Cavalca, Viviana
PY - 2009
Y1 - 2009
N2 - The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
AB - The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
KW - Coronary artery bypass graft
KW - Glutathione
KW - Malondialdehyde
KW - Oxidative stress global index
UR - http://www.scopus.com/inward/record.url?scp=70449395482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449395482&partnerID=8YFLogxK
U2 - 10.3109/13547500903134395
DO - 10.3109/13547500903134395
M3 - Article
VL - 14
SP - 465
EP - 472
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 7
ER -