Abstract
The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
| Original language | English |
|---|---|
| Pages (from-to) | 465-472 |
| Number of pages | 8 |
| Journal | Biomarkers |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 |
Keywords
- Coronary artery bypass graft
- Glutathione
- Malondialdehyde
- Oxidative stress global index
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
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Veglia, F., Werba, J. P., Tremoli, E., Squellerio, I., Sisillo, E., Parolari, A., Minardi, F., & Cavalca, V. (2009). Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers. Biomarkers, 14(7), 465-472. https://doi.org/10.3109/13547500903134395