Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers

Fabrizio Veglia, José P. Werba, Elena Tremoli, Isabella Squellerio, Erminio Sisillo, Alessandro Parolari, Fabiana Minardi, Viviana Cavalca

Research output: Contribution to journalArticle

Abstract

The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalBiomarkers
Volume14
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • Coronary artery bypass graft
  • Glutathione
  • Malondialdehyde
  • Oxidative stress global index

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers'. Together they form a unique fingerprint.

  • Cite this