TY - JOUR
T1 - Assessment of oxidative stress in coronary artery bypass surgery
T2 - Comparison between the global index OXY-SCORE and individual biomarkers
AU - Veglia, Fabrizio
AU - Werba, José P.
AU - Tremoli, Elena
AU - Squellerio, Isabella
AU - Sisillo, Erminio
AU - Parolari, Alessandro
AU - Minardi, Fabiana
AU - Cavalca, Viviana
PY - 2009
Y1 - 2009
N2 - The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
AB - The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
KW - Coronary artery bypass graft
KW - Glutathione
KW - Malondialdehyde
KW - Oxidative stress global index
UR - http://www.scopus.com/inward/record.url?scp=70449395482&partnerID=8YFLogxK
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U2 - 10.3109/13547500903134395
DO - 10.3109/13547500903134395
M3 - Article
C2 - 19863184
AN - SCOPUS:70449395482
VL - 14
SP - 465
EP - 472
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 7
ER -