Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers

Fabrizio Veglia; José P. Werba; Elena Tremoli; Isabella Squellerio; Erminio Sisillo; Alessandro Parolari; Fabiana Minardi; Viviana Cavalca

doi:10.3109/13547500903134395

Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers

Fabrizio Veglia, José P. Werba, Elena Tremoli, Isabella Squellerio, Erminio Sisillo, Alessandro Parolari, Fabiana Minardi, Viviana Cavalca

Research output: Contribution to journal › Article › peer-review

Abstract

The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.

Original language	English
Pages (from-to)	465-472
Number of pages	8
Journal	Biomarkers
Volume	14
Issue number	7
DOIs	https://doi.org/10.3109/13547500903134395
Publication status	Published - 2009

Keywords

Coronary artery bypass graft
Glutathione
Malondialdehyde
Oxidative stress global index

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/13547500903134395

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Assessment of oxidative stress in coronary artery bypass surgery : Comparison between the global index OXY-SCORE and individual biomarkers. / Veglia, Fabrizio ; Werba, José P.; Tremoli, Elena; Squellerio, Isabella; Sisillo, Erminio; Parolari, Alessandro; Minardi, Fabiana; Cavalca, Viviana.

In: Biomarkers, Vol. 14, No. 7, 2009, p. 465-472.

Research output: Contribution to journal › Article › peer-review

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AU - Squellerio, Isabella

AU - Sisillo, Erminio

AU - Parolari, Alessandro

AU - Minardi, Fabiana

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Assessment of oxidative stress in coronary artery bypass surgery: Comparison between the global index OXY-SCORE and individual biomarkers

Abstract

Keywords

ASJC Scopus subject areas

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