Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study

Costanzo Simona, Gaetano Donati de Katleen, Campana Lara, Marco Olivieri, Santangelo Rosaria, Sanguinetti Maurizio, Cauda Roberto, Iacoviello Licia

Research output: Contribution to journalArticle

Abstract

Background: Influenza vaccination protects high-risk populations from severe outcomes.

Methods: During the 2011-2012 flu season at "Gemelli Hospital" in Rome, all hospitalised patients who developed suspected influenza-like illness within 14 days were recruited to assess the feasibility of testing the influenza vaccine effectiveness against laboratory-confirmed influenza requiring hospitalisation.

Conclusions: No difference in vaccine status between patients with positive and negative laboratory tests was found due to the small sample size. Larger numbers are required to explore influenza vaccine effectiveness.

Results: Sixty-two patients were recruited; among them, 18 were laboratory confirmed for influenza A or B. In the target group for vaccination (N=47), the prevalence of vaccinated subjects was less than expected (38%).

Original languageEnglish
Pages (from-to)e9157-1-e9157-6
JournalEpidemiology Biostatistics and Public Health
Volume11
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Hospitalisation
  • Influenza vaccine effectiveness
  • Influenza-like illness
  • Pilot case-control study

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Community and Home Care

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