Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study

Costanzo Simona; Gaetano Donati de Katleen; Campana Lara; Marco Olivieri; Santangelo Rosaria; Sanguinetti Maurizio; Cauda Roberto; Iacoviello Licia

doi:10.2427/9157

Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study

Costanzo Simona, Gaetano Donati de Katleen, Campana Lara, Marco Olivieri, Santangelo Rosaria, Sanguinetti Maurizio, Cauda Roberto, Iacoviello Licia

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Research output: Contribution to journal › Article › peer-review

Abstract

Background: Influenza vaccination protects high-risk populations from severe outcomes.

Methods: During the 2011-2012 flu season at "Gemelli Hospital" in Rome, all hospitalised patients who developed suspected influenza-like illness within 14 days were recruited to assess the feasibility of testing the influenza vaccine effectiveness against laboratory-confirmed influenza requiring hospitalisation.

Conclusions: No difference in vaccine status between patients with positive and negative laboratory tests was found due to the small sample size. Larger numbers are required to explore influenza vaccine effectiveness.

Results: Sixty-two patients were recruited; among them, 18 were laboratory confirmed for influenza A or B. In the target group for vaccination (N=47), the prevalence of vaccinated subjects was less than expected (38%).

Original language	English
Pages (from-to)	e9157-1-e9157-6
Journal	Epidemiology Biostatistics and Public Health
Volume	11
Issue number	3
DOIs	https://doi.org/10.2427/9157
Publication status	Published - 2014

Keywords

Hospitalisation
Influenza vaccine effectiveness
Influenza-like illness
Pilot case-control study

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Community and Home Care

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10.2427/9157

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Simona, C., de Katleen, G. D., Lara, C., Olivieri, M., Rosaria, S., Maurizio, S., Roberto, C., & Licia, I. (2014). Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study. Epidemiology Biostatistics and Public Health, 11(3), e9157-1-e9157-6. https://doi.org/10.2427/9157

Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital : Pitfalls and intricacies from a pilot case-control study. / Simona, Costanzo; de Katleen, Gaetano Donati; Lara, Campana et al.

In: Epidemiology Biostatistics and Public Health, Vol. 11, No. 3, 2014, p. e9157-1-e9157-6.

Research output: Contribution to journal › Article › peer-review

Simona, C, de Katleen, GD, Lara, C, Olivieri, M, Rosaria, S, Maurizio, S, Roberto, C & Licia, I 2014, 'Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study', Epidemiology Biostatistics and Public Health, vol. 11, no. 3, pp. e9157-1-e9157-6. https://doi.org/10.2427/9157

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AU - Olivieri, Marco

AU - Rosaria, Santangelo

AU - Maurizio, Sanguinetti

AU - Roberto, Cauda

AU - Licia, Iacoviello

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AB - Background: Influenza vaccination protects high-risk populations from severe outcomes.Methods: During the 2011-2012 flu season at "Gemelli Hospital" in Rome, all hospitalised patients who developed suspected influenza-like illness within 14 days were recruited to assess the feasibility of testing the influenza vaccine effectiveness against laboratory-confirmed influenza requiring hospitalisation.Conclusions: No difference in vaccine status between patients with positive and negative laboratory tests was found due to the small sample size. Larger numbers are required to explore influenza vaccine effectiveness.Results: Sixty-two patients were recruited; among them, 18 were laboratory confirmed for influenza A or B. In the target group for vaccination (N=47), the prevalence of vaccinated subjects was less than expected (38%).

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Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: Pitfalls and intricacies from a pilot case-control study

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