Assessment of split renal function with99mTc-aprotinin

Carlo Aprile, Raffaella Saponaro, Giuseppe Villa, Mauro Carena, Fabio Lunghi, Sebastiano B. Solerte, Alessandro Salvadeo

Research output: Contribution to journalArticle

Abstract

The aim of this work is to correlate the net kidney uptake of99mTc-aprotinin (TcA) in 103 subjects with separate effective renal plasma flow (ERPF) and some blood chemistry parameters at 90, 180, and 360 min postinjection both in the normal and diseased kidney. Correlations found with separate ERPFs are highly significant at any time (P <0.001). However, although the slope of the regression line is steeper at 180 min, r tends to deteriorate slightly with time postinjection and a higher intercept on the y axis: this pattern is more pronounced if diseased kidneys are considered separately. The following are probably related to the renal handling of TcA: (1) Early scans better reflect blood flow to the kidney, while later scans are more related to the metabolism/excretion tubular mechanisms; (2) correlations found with urea, creatinine, urea clearance, and creatinine clearance are highly significant at any time; (3) in 20 additional patients with diseased kidneys, renal uptake measurements done 360 min postinjection first with TcA and then with DMSA showed better correlations with ERPF employing TcA. Our results indicate that TcA is a feasible indicator of split renal function even at 90 min postinjection when a scan is easily carried out on an outpatient basis.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalEuropean Journal Of Nuclear Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1986

Fingerprint

Aprotinin
Effective Renal Plasma Flow
Kidney
Kidney Diseases
Urea
Creatinine
Succimer
Outpatients

Keywords

  • Tc-Aprotinin
  • Tc-DMSA
  • ERPF
  • Kidney scan

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Aprile, C., Saponaro, R., Villa, G., Carena, M., Lunghi, F., Solerte, S. B., & Salvadeo, A. (1986). Assessment of split renal function with99mTc-aprotinin. European Journal Of Nuclear Medicine, 12(1), 37-40. https://doi.org/10.1007/BF00638793

Assessment of split renal function with99mTc-aprotinin. / Aprile, Carlo; Saponaro, Raffaella; Villa, Giuseppe; Carena, Mauro; Lunghi, Fabio; Solerte, Sebastiano B.; Salvadeo, Alessandro.

In: European Journal Of Nuclear Medicine, Vol. 12, No. 1, 01.1986, p. 37-40.

Research output: Contribution to journalArticle

Aprile, C, Saponaro, R, Villa, G, Carena, M, Lunghi, F, Solerte, SB & Salvadeo, A 1986, 'Assessment of split renal function with99mTc-aprotinin', European Journal Of Nuclear Medicine, vol. 12, no. 1, pp. 37-40. https://doi.org/10.1007/BF00638793
Aprile C, Saponaro R, Villa G, Carena M, Lunghi F, Solerte SB et al. Assessment of split renal function with99mTc-aprotinin. European Journal Of Nuclear Medicine. 1986 Jan;12(1):37-40. https://doi.org/10.1007/BF00638793
Aprile, Carlo ; Saponaro, Raffaella ; Villa, Giuseppe ; Carena, Mauro ; Lunghi, Fabio ; Solerte, Sebastiano B. ; Salvadeo, Alessandro. / Assessment of split renal function with99mTc-aprotinin. In: European Journal Of Nuclear Medicine. 1986 ; Vol. 12, No. 1. pp. 37-40.
@article{a958f77e8a844acf822a3f8738dfa274,
title = "Assessment of split renal function with99mTc-aprotinin",
abstract = "The aim of this work is to correlate the net kidney uptake of99mTc-aprotinin (TcA) in 103 subjects with separate effective renal plasma flow (ERPF) and some blood chemistry parameters at 90, 180, and 360 min postinjection both in the normal and diseased kidney. Correlations found with separate ERPFs are highly significant at any time (P <0.001). However, although the slope of the regression line is steeper at 180 min, r tends to deteriorate slightly with time postinjection and a higher intercept on the y axis: this pattern is more pronounced if diseased kidneys are considered separately. The following are probably related to the renal handling of TcA: (1) Early scans better reflect blood flow to the kidney, while later scans are more related to the metabolism/excretion tubular mechanisms; (2) correlations found with urea, creatinine, urea clearance, and creatinine clearance are highly significant at any time; (3) in 20 additional patients with diseased kidneys, renal uptake measurements done 360 min postinjection first with TcA and then with DMSA showed better correlations with ERPF employing TcA. Our results indicate that TcA is a feasible indicator of split renal function even at 90 min postinjection when a scan is easily carried out on an outpatient basis.",
keywords = "Tc-Aprotinin, Tc-DMSA, ERPF, Kidney scan",
author = "Carlo Aprile and Raffaella Saponaro and Giuseppe Villa and Mauro Carena and Fabio Lunghi and Solerte, {Sebastiano B.} and Alessandro Salvadeo",
year = "1986",
month = "1",
doi = "10.1007/BF00638793",
language = "English",
volume = "12",
pages = "37--40",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Berlin Heidelberg",
number = "1",

}

TY - JOUR

T1 - Assessment of split renal function with99mTc-aprotinin

AU - Aprile, Carlo

AU - Saponaro, Raffaella

AU - Villa, Giuseppe

AU - Carena, Mauro

AU - Lunghi, Fabio

AU - Solerte, Sebastiano B.

AU - Salvadeo, Alessandro

PY - 1986/1

Y1 - 1986/1

N2 - The aim of this work is to correlate the net kidney uptake of99mTc-aprotinin (TcA) in 103 subjects with separate effective renal plasma flow (ERPF) and some blood chemistry parameters at 90, 180, and 360 min postinjection both in the normal and diseased kidney. Correlations found with separate ERPFs are highly significant at any time (P <0.001). However, although the slope of the regression line is steeper at 180 min, r tends to deteriorate slightly with time postinjection and a higher intercept on the y axis: this pattern is more pronounced if diseased kidneys are considered separately. The following are probably related to the renal handling of TcA: (1) Early scans better reflect blood flow to the kidney, while later scans are more related to the metabolism/excretion tubular mechanisms; (2) correlations found with urea, creatinine, urea clearance, and creatinine clearance are highly significant at any time; (3) in 20 additional patients with diseased kidneys, renal uptake measurements done 360 min postinjection first with TcA and then with DMSA showed better correlations with ERPF employing TcA. Our results indicate that TcA is a feasible indicator of split renal function even at 90 min postinjection when a scan is easily carried out on an outpatient basis.

AB - The aim of this work is to correlate the net kidney uptake of99mTc-aprotinin (TcA) in 103 subjects with separate effective renal plasma flow (ERPF) and some blood chemistry parameters at 90, 180, and 360 min postinjection both in the normal and diseased kidney. Correlations found with separate ERPFs are highly significant at any time (P <0.001). However, although the slope of the regression line is steeper at 180 min, r tends to deteriorate slightly with time postinjection and a higher intercept on the y axis: this pattern is more pronounced if diseased kidneys are considered separately. The following are probably related to the renal handling of TcA: (1) Early scans better reflect blood flow to the kidney, while later scans are more related to the metabolism/excretion tubular mechanisms; (2) correlations found with urea, creatinine, urea clearance, and creatinine clearance are highly significant at any time; (3) in 20 additional patients with diseased kidneys, renal uptake measurements done 360 min postinjection first with TcA and then with DMSA showed better correlations with ERPF employing TcA. Our results indicate that TcA is a feasible indicator of split renal function even at 90 min postinjection when a scan is easily carried out on an outpatient basis.

KW - Tc-Aprotinin

KW - Tc-DMSA

KW - ERPF

KW - Kidney scan

UR - http://www.scopus.com/inward/record.url?scp=0022549139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022549139&partnerID=8YFLogxK

U2 - 10.1007/BF00638793

DO - 10.1007/BF00638793

M3 - Article

C2 - 2426112

AN - SCOPUS:0022549139

VL - 12

SP - 37

EP - 40

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 1

ER -