Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease

Paola Cordiali-Fei, Anna Mussi, Giovanna D'Agosto, Elisabetta Trento, Valentina Bordignon, Silvana Trincone, Antonella Vento, Isabella Sperduti, Antonio Cristaudo, Fabrizio Ensoli

Research output: Contribution to journalArticle

Abstract

In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression.

Original languageEnglish
Article number390563
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013

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Connective Tissue Diseases
Systemic Scleroderma
Regulatory T-Lymphocytes
Autoantibodies
Biomarkers
Antibodies
Antigens
Type I DNA Topoisomerase
Autoimmune Diseases
Signs and Symptoms
Antibody Formation
Disease Progression
Serum

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

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title = "Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease",
abstract = "In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression.",
author = "Paola Cordiali-Fei and Anna Mussi and Giovanna D'Agosto and Elisabetta Trento and Valentina Bordignon and Silvana Trincone and Antonella Vento and Isabella Sperduti and Antonio Cristaudo and Fabrizio Ensoli",
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T1 - Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease

AU - Cordiali-Fei, Paola

AU - Mussi, Anna

AU - D'Agosto, Giovanna

AU - Trento, Elisabetta

AU - Bordignon, Valentina

AU - Trincone, Silvana

AU - Vento, Antonella

AU - Sperduti, Isabella

AU - Cristaudo, Antonio

AU - Ensoli, Fabrizio

PY - 2013

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