Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: The DEFIND study

Manuel Luque Otero; Gilberto Parisi; Angelo Maffei; Carmine Vecchione; Giuseppe Lembo

Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: The DEFIND study

Manuel Luque Otero, Gilberto Parisi, Angelo Maffei, Carmine Vecchione, Giuseppe Lembo

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Abstract

This study was undertaken to compare and verify the antihypertensive effects of various delapril doses versus placebo on office and ambulatory blood pressure (BP). After a 2-wk placebo period, 303 patients with mild to moderate essential hypertension were randomized in a double-blind study to 8 wk of treatment with placebo, or delapril 7.5 mg twice daily, delapril 15 mg twice daily, delapril 30 mg twice daily, or delapril 30 mg once daily. BP changes versus baseline and rates of normalized office systolic blood pressure (SBP)

Original language	English
Pages (from-to)	421-432
Number of pages	12
Journal	Advances in Therapy
Volume	23
Issue number	3
Publication status	Published - May 2006

Keywords

Ambulatory blood pressure monitoring
Delapril
Essential hypertension
Office blood pressure
Placebo
Randomized trial

ASJC Scopus subject areas

Medicine(all)

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abstract = "This study was undertaken to compare and verify the antihypertensive effects of various delapril doses versus placebo on office and ambulatory blood pressure (BP). After a 2-wk placebo period, 303 patients with mild to moderate essential hypertension were randomized in a double-blind study to 8 wk of treatment with placebo, or delapril 7.5 mg twice daily, delapril 15 mg twice daily, delapril 30 mg twice daily, or delapril 30 mg once daily. BP changes versus baseline and rates of normalized office systolic blood pressure (SBP) ",

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AU - Otero, Manuel Luque

AU - Parisi, Gilberto

AU - Maffei, Angelo

AU - Vecchione, Carmine

AU - Lembo, Giuseppe

PY - 2006/5

Y1 - 2006/5

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AB - This study was undertaken to compare and verify the antihypertensive effects of various delapril doses versus placebo on office and ambulatory blood pressure (BP). After a 2-wk placebo period, 303 patients with mild to moderate essential hypertension were randomized in a double-blind study to 8 wk of treatment with placebo, or delapril 7.5 mg twice daily, delapril 15 mg twice daily, delapril 30 mg twice daily, or delapril 30 mg once daily. BP changes versus baseline and rates of normalized office systolic blood pressure (SBP)

KW - Ambulatory blood pressure monitoring

KW - Delapril

KW - Essential hypertension

KW - Office blood pressure

KW - Placebo

KW - Randomized trial

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Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: The DEFIND study

Abstract

Keywords

ASJC Scopus subject areas

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