Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: The DEFIND study

Manuel Luque Otero, Gilberto Parisi, Angelo Maffei, Carmine Vecchione, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review

Abstract

This study was undertaken to compare and verify the antihypertensive effects of various delapril doses versus placebo on office and ambulatory blood pressure (BP). After a 2-wk placebo period, 303 patients with mild to moderate essential hypertension were randomized in a double-blind study to 8 wk of treatment with placebo, or delapril 7.5 mg twice daily, delapril 15 mg twice daily, delapril 30 mg twice daily, or delapril 30 mg once daily. BP changes versus baseline and rates of normalized office systolic blood pressure (SBP)

Original languageEnglish
Pages (from-to)421-432
Number of pages12
JournalAdvances in Therapy
Volume23
Issue number3
Publication statusPublished - May 2006

Keywords

  • Ambulatory blood pressure monitoring
  • Delapril
  • Essential hypertension
  • Office blood pressure
  • Placebo
  • Randomized trial

ASJC Scopus subject areas

  • Medicine(all)

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