Assessment of the arterial input function for estimation of coronary flow reserve by single photon emission computed tomography: Comparison of two different approaches

Giovanni Storto, Andrea Soricelli, Teresa Pellegrino, Mario Petretta, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Attempts to estimate coronary flow reserve (CFR) with single photon emission computed tomography (SPECT) tracers have been recently made. We compared two different methods for the estimation of CFR by SPECT imaging. Methods: Fourteen patients with coronary artery disease underwent dipyridamole 99mTc-sestamibi SPECT and intracoronary Doppler within 5 days. Myocardial blood flow (MBF) was estimated by measurement of first transit counts in the right pulmonary artery (PA) and left ventricular (LV) chamber, and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of stress MBF to rest MBF. Results: Rest and stress MBF obtained using first transit counts from PA were higher compared to that from LV chamber (rest: 1.05±0.38 vs 0.87±0.34 counts/pixel per s, respectively, p

Original languageEnglish
Pages (from-to)2034-2041
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Arterial input function
  • Coronary flow reserve
  • Sestamibi imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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