Assessment of the coupling between RT(apex) and RR interval as an index of temporal dispersion of ventricular repolarization

F. Lombardi, A. Colombo, A. Porta, G. Baselli, S. Cerutti, C. Fiorentini

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the dynamic characteristics of the relationship between the RT and RR intervals we analyzed the RR/RT(apex) variability interaction with a dynamic parametric model whose parameters can be directly estimated from the beat-to-beat series RR and RT(apex), intervals. The model is designed to separate the fraction or RT(apex) variability driven by RR changes from that independent of RR variations and to quantify the gain and phase of the relationship between RR and RT(apex) intervals. The percentage of RT(apex) variability driven by RR variability was significantly greater in young normal subjects in comparison with postmyocardial infarction patients as well as with age-matched control subjects. This new approach based on the quantification of the RT(apex) variability dependent and independent of beat- to-beat RR interval changes could be used to quantify the degree of uncoupling between the two signals thus providing a new and noninvasive index of temporal dispersion of ventricular repolarization.

Original languageEnglish
Pages (from-to)2396-2400
Number of pages5
JournalPACE - Pacing and Clinical Electrophysiology
Volume21
Issue number11 II
Publication statusPublished - 1998

Keywords

  • QT dispersion
  • QT interval
  • Spectral analysis
  • Ventricular repolarization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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