Assessment of the epithelium's contribution to corneal biomechanics

Ahmed Elsheikh, Daad Alhasso, Paolo Rama

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Determining the epithelium's contribution to corneal biomechanics is important for the predictive numerical simulation of corneal biomechanical behaviour in which the cornea's five main layers are represented separately. Twenty-four corneal buttons were tested under posterior inflation conditions while monitoring their behaviour using non-contact methods. The corneas were divided into two groups of 12; one with and one without the epithelium. Control of specimen hydration, temperature and pressure application rate, and limiting the programme to specimens within a small age range resulted in a narrow scatter of test results. On average, intact specimens were able to carry slightly more pressure at the same deformation, and experienced less average stress for the same strain, compared with specimens without the epithelium. These results indicated that the stiffness of the epithelium was considerably lower than that of the stroma, and might therefore be ignored in numerical simulation studies.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalExperimental Eye Research
Volume86
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Biomechanical Phenomena
Epithelium
Cornea
Pressure
Economic Inflation
Temperature

Keywords

  • biomechanics
  • cornea
  • epithelium
  • experimental testing

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Assessment of the epithelium's contribution to corneal biomechanics. / Elsheikh, Ahmed; Alhasso, Daad; Rama, Paolo.

In: Experimental Eye Research, Vol. 86, No. 2, 02.2008, p. 445-451.

Research output: Contribution to journalArticle

Elsheikh, Ahmed ; Alhasso, Daad ; Rama, Paolo. / Assessment of the epithelium's contribution to corneal biomechanics. In: Experimental Eye Research. 2008 ; Vol. 86, No. 2. pp. 445-451.
@article{1763516bc3bf4b5999eb0dc2d678e148,
title = "Assessment of the epithelium's contribution to corneal biomechanics",
abstract = "Determining the epithelium's contribution to corneal biomechanics is important for the predictive numerical simulation of corneal biomechanical behaviour in which the cornea's five main layers are represented separately. Twenty-four corneal buttons were tested under posterior inflation conditions while monitoring their behaviour using non-contact methods. The corneas were divided into two groups of 12; one with and one without the epithelium. Control of specimen hydration, temperature and pressure application rate, and limiting the programme to specimens within a small age range resulted in a narrow scatter of test results. On average, intact specimens were able to carry slightly more pressure at the same deformation, and experienced less average stress for the same strain, compared with specimens without the epithelium. These results indicated that the stiffness of the epithelium was considerably lower than that of the stroma, and might therefore be ignored in numerical simulation studies.",
keywords = "biomechanics, cornea, epithelium, experimental testing",
author = "Ahmed Elsheikh and Daad Alhasso and Paolo Rama",
year = "2008",
month = "2",
doi = "10.1016/j.exer.2007.12.002",
language = "English",
volume = "86",
pages = "445--451",
journal = "Experimental Eye Research",
issn = "0014-4835",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Assessment of the epithelium's contribution to corneal biomechanics

AU - Elsheikh, Ahmed

AU - Alhasso, Daad

AU - Rama, Paolo

PY - 2008/2

Y1 - 2008/2

N2 - Determining the epithelium's contribution to corneal biomechanics is important for the predictive numerical simulation of corneal biomechanical behaviour in which the cornea's five main layers are represented separately. Twenty-four corneal buttons were tested under posterior inflation conditions while monitoring their behaviour using non-contact methods. The corneas were divided into two groups of 12; one with and one without the epithelium. Control of specimen hydration, temperature and pressure application rate, and limiting the programme to specimens within a small age range resulted in a narrow scatter of test results. On average, intact specimens were able to carry slightly more pressure at the same deformation, and experienced less average stress for the same strain, compared with specimens without the epithelium. These results indicated that the stiffness of the epithelium was considerably lower than that of the stroma, and might therefore be ignored in numerical simulation studies.

AB - Determining the epithelium's contribution to corneal biomechanics is important for the predictive numerical simulation of corneal biomechanical behaviour in which the cornea's five main layers are represented separately. Twenty-four corneal buttons were tested under posterior inflation conditions while monitoring their behaviour using non-contact methods. The corneas were divided into two groups of 12; one with and one without the epithelium. Control of specimen hydration, temperature and pressure application rate, and limiting the programme to specimens within a small age range resulted in a narrow scatter of test results. On average, intact specimens were able to carry slightly more pressure at the same deformation, and experienced less average stress for the same strain, compared with specimens without the epithelium. These results indicated that the stiffness of the epithelium was considerably lower than that of the stroma, and might therefore be ignored in numerical simulation studies.

KW - biomechanics

KW - cornea

KW - epithelium

KW - experimental testing

UR - http://www.scopus.com/inward/record.url?scp=39149134885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149134885&partnerID=8YFLogxK

U2 - 10.1016/j.exer.2007.12.002

DO - 10.1016/j.exer.2007.12.002

M3 - Article

VL - 86

SP - 445

EP - 451

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

IS - 2

ER -