Assessment of the functional significance of coronary lesions using a monorail catheter

Carlo Briguori, Takahiro Nishida, Milena Adamian, Angelo Anzuini, Nicola Corvaja, Mauro Carlino, Antonio Colombo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Myocardial fractional flow reserve (FFR) <0.75 is a reliable index of a functionally severe coronary stenosis. FFR is best assessed by a sensor-tipped pressure-monitoring guidewire (PW). The purpose of this study was to assess whether a multifunctional probing catheter (MFP), a 3 French dual-lumen monorail catheter, can be used to accurately measure intracoronary pressure and FFR. In 35 lesions (35 patients; learning group), we calculated FFR by both PW (FFRPW) and MFP (FFRMFP). Using ROC analysis, the FFRMFP value of 0.65 had the highest sensitivity with the FFRPW <0.75. FFRMFP cut-off (> 0.65) was tested in 40 patients (testing group). In all cases, lumen diameter was documented by an intracoronary ultrasound examination. In the learning group, the FFRPW was 0.82 ± 0.17 and FFRMFP was 0.70 ± 0.23 (r = 0.88; p <0.001). The FFRMFP cut-off value (0.65) correctly predicted the FFRPW in 37/40 cases in the testing group. In the 3 discordant cases, FFR was critical (<0.65) by MFP and normal (> 0.75) by PW. In all these cases, minimal lumen cross-sectional area was <2.8 mm2. When FFRMFP is > 0.65, FFRPW is always > 0.75. These data demonstrate that even with larger cross-sectional area than a pressure wire, the MFP catheter can easily and reliably be used to assess the functional severity of coronary stenoses.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalJournal of Invasive Cardiology
Volume13
Issue number4
Publication statusPublished - Apr 2001

Fingerprint

Myocardial Fractional Flow Reserve
Coronary Stenosis
Catheters
Learning
Pressure

Keywords

  • Coronary stenosis
  • Fractional flow reserve
  • Intravascular ultrasound

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Briguori, C., Nishida, T., Adamian, M., Anzuini, A., Corvaja, N., Carlino, M., & Colombo, A. (2001). Assessment of the functional significance of coronary lesions using a monorail catheter. Journal of Invasive Cardiology, 13(4), 279-286.

Assessment of the functional significance of coronary lesions using a monorail catheter. / Briguori, Carlo; Nishida, Takahiro; Adamian, Milena; Anzuini, Angelo; Corvaja, Nicola; Carlino, Mauro; Colombo, Antonio.

In: Journal of Invasive Cardiology, Vol. 13, No. 4, 04.2001, p. 279-286.

Research output: Contribution to journalArticle

Briguori, C, Nishida, T, Adamian, M, Anzuini, A, Corvaja, N, Carlino, M & Colombo, A 2001, 'Assessment of the functional significance of coronary lesions using a monorail catheter', Journal of Invasive Cardiology, vol. 13, no. 4, pp. 279-286.
Briguori C, Nishida T, Adamian M, Anzuini A, Corvaja N, Carlino M et al. Assessment of the functional significance of coronary lesions using a monorail catheter. Journal of Invasive Cardiology. 2001 Apr;13(4):279-286.
Briguori, Carlo ; Nishida, Takahiro ; Adamian, Milena ; Anzuini, Angelo ; Corvaja, Nicola ; Carlino, Mauro ; Colombo, Antonio. / Assessment of the functional significance of coronary lesions using a monorail catheter. In: Journal of Invasive Cardiology. 2001 ; Vol. 13, No. 4. pp. 279-286.
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