Assessment of the hypnotic/sedative effects and toxicity of Passiflora edulis aqueous extract in rodents and humans

E. Maluf, H. M T Baros, M. L. Frochtengarten, R. Benti, J. R. Leite

Research output: Contribution to journalArticlepeer-review

Abstract

Passiflora species are used in folk medicine as hypnotic and sedative treatments. In this study the hypnotic-sedative effects and toxicity of Passiflora edulis were assessed in rats and mice and in healthy volunteers. It was verified that some samples of Pasiflora edulis had a nonspecific central nervous system depressant effect. Furthermore, hepatobiliary and pancreatic toxicity to animals and humans were detected.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalPhytotherapy Research
Volume5
Issue number6
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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