Assessment of the potential malignancy of Epstein-Barr virus (EBV)-infected B cells in AIDS-related disorders.

S. Roncella, P. Caretto, G. Forni, G. Cutrona, A. Verde, D. Ramarli, P. F. de Celle, R. Foá, M. Sessarego, V. Pistoia

Research output: Contribution to journalArticle

Abstract

Spontaneous lymphoblastoid cell lines (LCLs) were established from the peripheral blood of ten human immunodeficiency virus (HIV)-seropositive patients in order to investigate whether or not a progression of the cells toward a malignant state could be traced. The LCLs studied displayed no differences in their surface phenotype, karyotype, or tumorigenicity in nude mice when compared with a wide panel of control LCLs. However, four of the ten LCLs derived from HIV-seropositive patients formed colonies in agar with a cloning efficiency (0.1 to 0.9%) that was much lower than that of a control neoplastic B cell line (50%). Some sublines that were derived form the agar colonies expressed new activation markers (CD10 and Bac-1) but did not produce tumors in nude mice or display chromosomal abnormalities. These sublines might comprise cells that have progressed toward a more transformed state.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalCancer Detection and Prevention
Volume14
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research

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    Roncella, S., Caretto, P., Forni, G., Cutrona, G., Verde, A., Ramarli, D., de Celle, P. F., Foá, R., Sessarego, M., & Pistoia, V. (1990). Assessment of the potential malignancy of Epstein-Barr virus (EBV)-infected B cells in AIDS-related disorders. Cancer Detection and Prevention, 14(3), 325-329.