Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors

Elisabetta Romagnoli, Carla Lubrano, Vincenzo Carnevale, Daniela Costantini, Luciano Nieddu, Susanna Morano, Silvia Migliaccio, Lucio Gnessi, Andrea Lenzi

Research output: Contribution to journalArticlepeer-review

Abstract

The “trabecular bone score” (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and some parameters of glucose metabolism, sex-and calciotropic hormone levels. Regression models were adjusted for either age and BMI, or age and waist circumference, or age and waist/hip ratio, also considering BMI >35 (y/n) and metabolic syndrome (MS) (y/n). Correlations between TBS and parameters studied were higher when correcting for waist circumference, although not significant in subjects with BMI >35. The analysis of covariance showed that the same model always had a higher adjusted r-square index. BMD at lumbar spine and total hip, fasting glucose, bioavailable testosterone, and sex hormone-binding globulin are the only covariates having a significant effect (p <0.05) on the variations of TBS. The presence of MS negatively affected only the association between TBS and BMD at total hip. We did not find any significant effect of BMI >35 on TBS values or significant interaction terms between each covariate and either BMI >35 or the presence of MS. Obesity negatively affected TBS, despite unchanged BMD. Alterations of glucose homeostasis and sex hormone levels seem to influence this relationship, while calciotropic hormones have no role. The effect of waist circumference on TBS is more pronounced than that of BMI.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEndocrine
DOIs
Publication statusAccepted/In press - Jan 27 2016

Keywords

  • Bone quality
  • Men
  • Metabolic syndrome
  • Obesity
  • TBS

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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