La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE

Translated title of the contribution: Assestment of the absolute global cardiovascular risk: Comparison betweeen the risk chart and the individual score of the CUORE Project

Simona Giampaoli, Luigi Palmieri, Chiara Donfrancesco, Salvatore Panico, Lorenza Pilotto, Antonio Addis, Alessandro Boccanelli, Giuseppe Di Pasquale, Ovidio Brignoli, Alessandro Filippi, Diego Vanuzzo, F. Dima, C. Lo Noce, L. Palmieri, M. Trojam, F. Valagussa, S. Pede, M. Uguccioni, C. Riccio, P. VerdecchiaG. F. Mureddu, A. Boccanelli, A. Maggioni, F. Colivicchi, P. Mocarelli, M. Bertona, P. Brambilla, S. Signorini, V. Martinelli, R. Pelizza, P. A. Rovazzi, M. Vona, M. A. Savio, M. De Marchi, M. L. Biorci, R. Griffo, G. Gullace, M. Villa, G. Gullace, F. Tettamanti, D. Bernasconi, G. Ferrari, F. Avanzini, L. Salvagnin, M. M. Martini, D. Mazzoleni, A. Colombi, A. Casari, I. Pastine, M. N. Mori, G. Gigli, A. Pizzuti, M. A. Testa, M. Di Leo, G. Cucchi, B. Baldini, S. Giustiniani, M. G. Sclavo, E. FerTaris, E. Commodo, R. Pedretti, S. Belbusti, R. Pedretti, F. Soffiantino, M. Castelletta, P. Giannuzzi, D. Girardini, G. Rudari, G. Vergara, A. Pozzati, S. Bovinelli, G. Di Pasquale, S. Boni, R. Carrirolo, S. Biagio, G. Rigatelli, G. Candelpergher, R. P. Tamai, L. Celegon, E. Cremaschi, M. Massari, G. Bruno, C. A. Goldoni, M. Barbolini, F. Cioppi, C. Marchini, G. Piovaccari, L. Roncon, M. Tramarin, P. Zonzin, G. Zanata, E. Miotto, M. Siega, G. L. Nicolosi, P. Spolaore, C. Rizzato, A. Fontanelli, L. Quattrini, A. Budini

Research output: Contribution to journalArticle

Abstract

Background. To evaluate 10-year cardiovascular risk, the risk chart and the individual risk score from he CUORE Project were recently introduced in Italy. These tools differ as for age range and some risk factors. Therefore, the aim of this study is to evaluate the difference between the global absolute risk assessed by the risk chart and the individual risk score using the data collected through the Osservatorio Epidemiologico Cardiovascolare (OEC). Methods. From the Osservatorio Epidemiologico Cardiovascolare sample, 6508 people aged 40-69 years without clinical manifestations of atherosclerosis were selected. Cardiovascular risk was assessed using risk chart and individual risk score and the 10-year risk was categorized in six classes (<5%, 5-9%, 10-14%, 15-19%, 20-29%, ≥ 30 %). As coefficient of agreement between risk chart and individual risk score, Cohen kappa statistic was computed using the Ciechetti-Allison weights (kw). Results. From contingency tables of the two methods distribution, kw was 0.71 (p <0.0001 and 95% confidence interval 0.70-0.72). Using the 20% risk threshold reported in Nota 13 of Agenzia Italiana del Farmaco and excluding persons who were treated for hyperlipemia refunded regardless of their chart or individual score estimation of cardiovascular risk, the differences between the two tools classification resulted in the 2.6% of the sample (1.4% were assessed as at non-high risk [<20%] using the risk chart and at high risk using the individual risk score, and the opposite for 1.2%). Conclusions. Classification difference between risk charts and the individual risk score is quite small. Updating of predictive functions of two tools could improve their concordance also for individual evaluation, including older people and better reflecting current Italian lifestyle.

Original languageItalian
Pages (from-to)359-364
Number of pages6
JournalGiornale Italiano di Cardiologia
Volume7
Issue number5
Publication statusPublished - May 2006

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Hyperlipidemias
Italy
Life Style
Atherosclerosis
Confidence Intervals
Weights and Measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Giampaoli, S., Palmieri, L., Donfrancesco, C., Panico, S., Pilotto, L., Addis, A., ... Budini, A. (2006). La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE. Giornale Italiano di Cardiologia, 7(5), 359-364.

La valutazione del rischio cardiovascolare globale assoluto : Confronto tra carta e punteggio del Progetto CUORE. / Giampaoli, Simona; Palmieri, Luigi; Donfrancesco, Chiara; Panico, Salvatore; Pilotto, Lorenza; Addis, Antonio; Boccanelli, Alessandro; Di Pasquale, Giuseppe; Brignoli, Ovidio; Filippi, Alessandro; Vanuzzo, Diego; Dima, F.; Lo Noce, C.; Palmieri, L.; Trojam, M.; Valagussa, F.; Pede, S.; Uguccioni, M.; Riccio, C.; Verdecchia, P.; Mureddu, G. F.; Boccanelli, A.; Maggioni, A.; Colivicchi, F.; Mocarelli, P.; Bertona, M.; Brambilla, P.; Signorini, S.; Martinelli, V.; Pelizza, R.; Rovazzi, P. A.; Vona, M.; Savio, M. A.; De Marchi, M.; Biorci, M. L.; Griffo, R.; Gullace, G.; Villa, M.; Gullace, G.; Tettamanti, F.; Bernasconi, D.; Ferrari, G.; Avanzini, F.; Salvagnin, L.; Martini, M. M.; Mazzoleni, D.; Colombi, A.; Casari, A.; Pastine, I.; Mori, M. N.; Gigli, G.; Pizzuti, A.; Testa, M. A.; Di Leo, M.; Cucchi, G.; Baldini, B.; Giustiniani, S.; Sclavo, M. G.; FerTaris, E.; Commodo, E.; Pedretti, R.; Belbusti, S.; Pedretti, R.; Soffiantino, F.; Castelletta, M.; Giannuzzi, P.; Girardini, D.; Rudari, G.; Vergara, G.; Pozzati, A.; Bovinelli, S.; Di Pasquale, G.; Boni, S.; Carrirolo, R.; Biagio, S.; Rigatelli, G.; Candelpergher, G.; Tamai, R. P.; Celegon, L.; Cremaschi, E.; Massari, M.; Bruno, G.; Goldoni, C. A.; Barbolini, M.; Cioppi, F.; Marchini, C.; Piovaccari, G.; Roncon, L.; Tramarin, M.; Zonzin, P.; Zanata, G.; Miotto, E.; Siega, M.; Nicolosi, G. L.; Spolaore, P.; Rizzato, C.; Fontanelli, A.; Quattrini, L.; Budini, A.

In: Giornale Italiano di Cardiologia, Vol. 7, No. 5, 05.2006, p. 359-364.

Research output: Contribution to journalArticle

Giampaoli, S, Palmieri, L, Donfrancesco, C, Panico, S, Pilotto, L, Addis, A, Boccanelli, A, Di Pasquale, G, Brignoli, O, Filippi, A, Vanuzzo, D, Dima, F, Lo Noce, C, Palmieri, L, Trojam, M, Valagussa, F, Pede, S, Uguccioni, M, Riccio, C, Verdecchia, P, Mureddu, GF, Boccanelli, A, Maggioni, A, Colivicchi, F, Mocarelli, P, Bertona, M, Brambilla, P, Signorini, S, Martinelli, V, Pelizza, R, Rovazzi, PA, Vona, M, Savio, MA, De Marchi, M, Biorci, ML, Griffo, R, Gullace, G, Villa, M, Gullace, G, Tettamanti, F, Bernasconi, D, Ferrari, G, Avanzini, F, Salvagnin, L, Martini, MM, Mazzoleni, D, Colombi, A, Casari, A, Pastine, I, Mori, MN, Gigli, G, Pizzuti, A, Testa, MA, Di Leo, M, Cucchi, G, Baldini, B, Giustiniani, S, Sclavo, MG, FerTaris, E, Commodo, E, Pedretti, R, Belbusti, S, Pedretti, R, Soffiantino, F, Castelletta, M, Giannuzzi, P, Girardini, D, Rudari, G, Vergara, G, Pozzati, A, Bovinelli, S, Di Pasquale, G, Boni, S, Carrirolo, R, Biagio, S, Rigatelli, G, Candelpergher, G, Tamai, RP, Celegon, L, Cremaschi, E, Massari, M, Bruno, G, Goldoni, CA, Barbolini, M, Cioppi, F, Marchini, C, Piovaccari, G, Roncon, L, Tramarin, M, Zonzin, P, Zanata, G, Miotto, E, Siega, M, Nicolosi, GL, Spolaore, P, Rizzato, C, Fontanelli, A, Quattrini, L & Budini, A 2006, 'La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE', Giornale Italiano di Cardiologia, vol. 7, no. 5, pp. 359-364.
Giampaoli S, Palmieri L, Donfrancesco C, Panico S, Pilotto L, Addis A et al. La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE. Giornale Italiano di Cardiologia. 2006 May;7(5):359-364.
Giampaoli, Simona ; Palmieri, Luigi ; Donfrancesco, Chiara ; Panico, Salvatore ; Pilotto, Lorenza ; Addis, Antonio ; Boccanelli, Alessandro ; Di Pasquale, Giuseppe ; Brignoli, Ovidio ; Filippi, Alessandro ; Vanuzzo, Diego ; Dima, F. ; Lo Noce, C. ; Palmieri, L. ; Trojam, M. ; Valagussa, F. ; Pede, S. ; Uguccioni, M. ; Riccio, C. ; Verdecchia, P. ; Mureddu, G. F. ; Boccanelli, A. ; Maggioni, A. ; Colivicchi, F. ; Mocarelli, P. ; Bertona, M. ; Brambilla, P. ; Signorini, S. ; Martinelli, V. ; Pelizza, R. ; Rovazzi, P. A. ; Vona, M. ; Savio, M. A. ; De Marchi, M. ; Biorci, M. L. ; Griffo, R. ; Gullace, G. ; Villa, M. ; Gullace, G. ; Tettamanti, F. ; Bernasconi, D. ; Ferrari, G. ; Avanzini, F. ; Salvagnin, L. ; Martini, M. M. ; Mazzoleni, D. ; Colombi, A. ; Casari, A. ; Pastine, I. ; Mori, M. N. ; Gigli, G. ; Pizzuti, A. ; Testa, M. A. ; Di Leo, M. ; Cucchi, G. ; Baldini, B. ; Giustiniani, S. ; Sclavo, M. G. ; FerTaris, E. ; Commodo, E. ; Pedretti, R. ; Belbusti, S. ; Pedretti, R. ; Soffiantino, F. ; Castelletta, M. ; Giannuzzi, P. ; Girardini, D. ; Rudari, G. ; Vergara, G. ; Pozzati, A. ; Bovinelli, S. ; Di Pasquale, G. ; Boni, S. ; Carrirolo, R. ; Biagio, S. ; Rigatelli, G. ; Candelpergher, G. ; Tamai, R. P. ; Celegon, L. ; Cremaschi, E. ; Massari, M. ; Bruno, G. ; Goldoni, C. A. ; Barbolini, M. ; Cioppi, F. ; Marchini, C. ; Piovaccari, G. ; Roncon, L. ; Tramarin, M. ; Zonzin, P. ; Zanata, G. ; Miotto, E. ; Siega, M. ; Nicolosi, G. L. ; Spolaore, P. ; Rizzato, C. ; Fontanelli, A. ; Quattrini, L. ; Budini, A. / La valutazione del rischio cardiovascolare globale assoluto : Confronto tra carta e punteggio del Progetto CUORE. In: Giornale Italiano di Cardiologia. 2006 ; Vol. 7, No. 5. pp. 359-364.
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abstract = "Background. To evaluate 10-year cardiovascular risk, the risk chart and the individual risk score from he CUORE Project were recently introduced in Italy. These tools differ as for age range and some risk factors. Therefore, the aim of this study is to evaluate the difference between the global absolute risk assessed by the risk chart and the individual risk score using the data collected through the Osservatorio Epidemiologico Cardiovascolare (OEC). Methods. From the Osservatorio Epidemiologico Cardiovascolare sample, 6508 people aged 40-69 years without clinical manifestations of atherosclerosis were selected. Cardiovascular risk was assessed using risk chart and individual risk score and the 10-year risk was categorized in six classes (<5{\%}, 5-9{\%}, 10-14{\%}, 15-19{\%}, 20-29{\%}, ≥ 30 {\%}). As coefficient of agreement between risk chart and individual risk score, Cohen kappa statistic was computed using the Ciechetti-Allison weights (kw). Results. From contingency tables of the two methods distribution, kw was 0.71 (p <0.0001 and 95{\%} confidence interval 0.70-0.72). Using the 20{\%} risk threshold reported in Nota 13 of Agenzia Italiana del Farmaco and excluding persons who were treated for hyperlipemia refunded regardless of their chart or individual score estimation of cardiovascular risk, the differences between the two tools classification resulted in the 2.6{\%} of the sample (1.4{\%} were assessed as at non-high risk [<20{\%}] using the risk chart and at high risk using the individual risk score, and the opposite for 1.2{\%}). Conclusions. Classification difference between risk charts and the individual risk score is quite small. Updating of predictive functions of two tools could improve their concordance also for individual evaluation, including older people and better reflecting current Italian lifestyle.",
keywords = "Epidemiology, Prevention, Risk factors",
author = "Simona Giampaoli and Luigi Palmieri and Chiara Donfrancesco and Salvatore Panico and Lorenza Pilotto and Antonio Addis and Alessandro Boccanelli and {Di Pasquale}, Giuseppe and Ovidio Brignoli and Alessandro Filippi and Diego Vanuzzo and F. Dima and {Lo Noce}, C. and L. Palmieri and M. Trojam and F. Valagussa and S. Pede and M. Uguccioni and C. Riccio and P. Verdecchia and Mureddu, {G. F.} and A. Boccanelli and A. Maggioni and F. Colivicchi and P. Mocarelli and M. Bertona and P. Brambilla and S. Signorini and V. Martinelli and R. Pelizza and Rovazzi, {P. A.} and M. Vona and Savio, {M. A.} and {De Marchi}, M. and Biorci, {M. L.} and R. Griffo and G. Gullace and M. Villa and G. Gullace and F. Tettamanti and D. Bernasconi and G. Ferrari and F. Avanzini and L. Salvagnin and Martini, {M. M.} and D. Mazzoleni and A. Colombi and A. Casari and I. Pastine and Mori, {M. N.} and G. Gigli and A. Pizzuti and Testa, {M. A.} and {Di Leo}, M. and G. Cucchi and B. Baldini and S. Giustiniani and Sclavo, {M. G.} and E. FerTaris and E. Commodo and R. Pedretti and S. Belbusti and R. Pedretti and F. Soffiantino and M. Castelletta and P. Giannuzzi and D. Girardini and G. Rudari and G. Vergara and A. Pozzati and S. Bovinelli and {Di Pasquale}, G. and S. Boni and R. Carrirolo and S. Biagio and G. Rigatelli and G. Candelpergher and Tamai, {R. P.} and L. Celegon and E. Cremaschi and M. Massari and G. Bruno and Goldoni, {C. A.} and M. Barbolini and F. Cioppi and C. Marchini and G. Piovaccari and L. Roncon and M. Tramarin and P. Zonzin and G. Zanata and E. Miotto and M. Siega and Nicolosi, {G. L.} and P. Spolaore and C. Rizzato and A. Fontanelli and L. Quattrini and A. Budini",
year = "2006",
month = "5",
language = "Italian",
volume = "7",
pages = "359--364",
journal = "Giornale Italiano di Cardiologia",
issn = "1827-6806",
publisher = "CEPI s.r.l.",
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TY - JOUR

T1 - La valutazione del rischio cardiovascolare globale assoluto

T2 - Confronto tra carta e punteggio del Progetto CUORE

AU - Giampaoli, Simona

AU - Palmieri, Luigi

AU - Donfrancesco, Chiara

AU - Panico, Salvatore

AU - Pilotto, Lorenza

AU - Addis, Antonio

AU - Boccanelli, Alessandro

AU - Di Pasquale, Giuseppe

AU - Brignoli, Ovidio

AU - Filippi, Alessandro

AU - Vanuzzo, Diego

AU - Dima, F.

AU - Lo Noce, C.

AU - Palmieri, L.

AU - Trojam, M.

AU - Valagussa, F.

AU - Pede, S.

AU - Uguccioni, M.

AU - Riccio, C.

AU - Verdecchia, P.

AU - Mureddu, G. F.

AU - Boccanelli, A.

AU - Maggioni, A.

AU - Colivicchi, F.

AU - Mocarelli, P.

AU - Bertona, M.

AU - Brambilla, P.

AU - Signorini, S.

AU - Martinelli, V.

AU - Pelizza, R.

AU - Rovazzi, P. A.

AU - Vona, M.

AU - Savio, M. A.

AU - De Marchi, M.

AU - Biorci, M. L.

AU - Griffo, R.

AU - Gullace, G.

AU - Villa, M.

AU - Gullace, G.

AU - Tettamanti, F.

AU - Bernasconi, D.

AU - Ferrari, G.

AU - Avanzini, F.

AU - Salvagnin, L.

AU - Martini, M. M.

AU - Mazzoleni, D.

AU - Colombi, A.

AU - Casari, A.

AU - Pastine, I.

AU - Mori, M. N.

AU - Gigli, G.

AU - Pizzuti, A.

AU - Testa, M. A.

AU - Di Leo, M.

AU - Cucchi, G.

AU - Baldini, B.

AU - Giustiniani, S.

AU - Sclavo, M. G.

AU - FerTaris, E.

AU - Commodo, E.

AU - Pedretti, R.

AU - Belbusti, S.

AU - Pedretti, R.

AU - Soffiantino, F.

AU - Castelletta, M.

AU - Giannuzzi, P.

AU - Girardini, D.

AU - Rudari, G.

AU - Vergara, G.

AU - Pozzati, A.

AU - Bovinelli, S.

AU - Di Pasquale, G.

AU - Boni, S.

AU - Carrirolo, R.

AU - Biagio, S.

AU - Rigatelli, G.

AU - Candelpergher, G.

AU - Tamai, R. P.

AU - Celegon, L.

AU - Cremaschi, E.

AU - Massari, M.

AU - Bruno, G.

AU - Goldoni, C. A.

AU - Barbolini, M.

AU - Cioppi, F.

AU - Marchini, C.

AU - Piovaccari, G.

AU - Roncon, L.

AU - Tramarin, M.

AU - Zonzin, P.

AU - Zanata, G.

AU - Miotto, E.

AU - Siega, M.

AU - Nicolosi, G. L.

AU - Spolaore, P.

AU - Rizzato, C.

AU - Fontanelli, A.

AU - Quattrini, L.

AU - Budini, A.

PY - 2006/5

Y1 - 2006/5

N2 - Background. To evaluate 10-year cardiovascular risk, the risk chart and the individual risk score from he CUORE Project were recently introduced in Italy. These tools differ as for age range and some risk factors. Therefore, the aim of this study is to evaluate the difference between the global absolute risk assessed by the risk chart and the individual risk score using the data collected through the Osservatorio Epidemiologico Cardiovascolare (OEC). Methods. From the Osservatorio Epidemiologico Cardiovascolare sample, 6508 people aged 40-69 years without clinical manifestations of atherosclerosis were selected. Cardiovascular risk was assessed using risk chart and individual risk score and the 10-year risk was categorized in six classes (<5%, 5-9%, 10-14%, 15-19%, 20-29%, ≥ 30 %). As coefficient of agreement between risk chart and individual risk score, Cohen kappa statistic was computed using the Ciechetti-Allison weights (kw). Results. From contingency tables of the two methods distribution, kw was 0.71 (p <0.0001 and 95% confidence interval 0.70-0.72). Using the 20% risk threshold reported in Nota 13 of Agenzia Italiana del Farmaco and excluding persons who were treated for hyperlipemia refunded regardless of their chart or individual score estimation of cardiovascular risk, the differences between the two tools classification resulted in the 2.6% of the sample (1.4% were assessed as at non-high risk [<20%] using the risk chart and at high risk using the individual risk score, and the opposite for 1.2%). Conclusions. Classification difference between risk charts and the individual risk score is quite small. Updating of predictive functions of two tools could improve their concordance also for individual evaluation, including older people and better reflecting current Italian lifestyle.

AB - Background. To evaluate 10-year cardiovascular risk, the risk chart and the individual risk score from he CUORE Project were recently introduced in Italy. These tools differ as for age range and some risk factors. Therefore, the aim of this study is to evaluate the difference between the global absolute risk assessed by the risk chart and the individual risk score using the data collected through the Osservatorio Epidemiologico Cardiovascolare (OEC). Methods. From the Osservatorio Epidemiologico Cardiovascolare sample, 6508 people aged 40-69 years without clinical manifestations of atherosclerosis were selected. Cardiovascular risk was assessed using risk chart and individual risk score and the 10-year risk was categorized in six classes (<5%, 5-9%, 10-14%, 15-19%, 20-29%, ≥ 30 %). As coefficient of agreement between risk chart and individual risk score, Cohen kappa statistic was computed using the Ciechetti-Allison weights (kw). Results. From contingency tables of the two methods distribution, kw was 0.71 (p <0.0001 and 95% confidence interval 0.70-0.72). Using the 20% risk threshold reported in Nota 13 of Agenzia Italiana del Farmaco and excluding persons who were treated for hyperlipemia refunded regardless of their chart or individual score estimation of cardiovascular risk, the differences between the two tools classification resulted in the 2.6% of the sample (1.4% were assessed as at non-high risk [<20%] using the risk chart and at high risk using the individual risk score, and the opposite for 1.2%). Conclusions. Classification difference between risk charts and the individual risk score is quite small. Updating of predictive functions of two tools could improve their concordance also for individual evaluation, including older people and better reflecting current Italian lifestyle.

KW - Epidemiology

KW - Prevention

KW - Risk factors

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UR - http://www.scopus.com/inward/citedby.url?scp=33745230034&partnerID=8YFLogxK

M3 - Articolo

C2 - 16752519

AN - SCOPUS:33745230034

VL - 7

SP - 359

EP - 364

JO - Giornale Italiano di Cardiologia

JF - Giornale Italiano di Cardiologia

SN - 1827-6806

IS - 5

ER -