La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE

Translated title of the contribution: Assestment of the absolute global cardiovascular risk: Comparison betweeen the risk chart and the individual score of the CUORE Project

Simona Giampaoli, Luigi Palmieri, Chiara Donfrancesco, Salvatore Panico, Lorenza Pilotto, Antonio Addis, Alessandro Boccanelli, Giuseppe Di Pasquale, Ovidio Brignoli, Alessandro Filippi, Diego Vanuzzo, F. Dima, C. Lo Noce, L. Palmieri, M. Trojam, F. Valagussa, S. Pede, M. Uguccioni, C. Riccio, P. VerdecchiaG. F. Mureddu, A. Boccanelli, A. Maggioni, F. Colivicchi, P. Mocarelli, M. Bertona, P. Brambilla, S. Signorini, V. Martinelli, R. Pelizza, P. A. Rovazzi, M. Vona, M. A. Savio, M. De Marchi, M. L. Biorci, R. Griffo, G. Gullace, M. Villa, G. Gullace, F. Tettamanti, D. Bernasconi, G. Ferrari, F. Avanzini, L. Salvagnin, M. M. Martini, D. Mazzoleni, A. Colombi, A. Casari, I. Pastine, M. N. Mori, G. Gigli, A. Pizzuti, M. A. Testa, M. Di Leo, G. Cucchi, B. Baldini, S. Giustiniani, M. G. Sclavo, E. FerTaris, E. Commodo, R. Pedretti, S. Belbusti, R. Pedretti, F. Soffiantino, M. Castelletta, P. Giannuzzi, D. Girardini, G. Rudari, G. Vergara, A. Pozzati, S. Bovinelli, G. Di Pasquale, S. Boni, R. Carrirolo, S. Biagio, G. Rigatelli, G. Candelpergher, R. P. Tamai, L. Celegon, E. Cremaschi, M. Massari, G. Bruno, C. A. Goldoni, M. Barbolini, F. Cioppi, C. Marchini, G. Piovaccari, L. Roncon, M. Tramarin, P. Zonzin, G. Zanata, E. Miotto, M. Siega, G. L. Nicolosi, P. Spolaore, C. Rizzato, A. Fontanelli, L. Quattrini, A. Budini

Research output: Contribution to journalArticle

Abstract

Background. To evaluate 10-year cardiovascular risk, the risk chart and the individual risk score from he CUORE Project were recently introduced in Italy. These tools differ as for age range and some risk factors. Therefore, the aim of this study is to evaluate the difference between the global absolute risk assessed by the risk chart and the individual risk score using the data collected through the Osservatorio Epidemiologico Cardiovascolare (OEC). Methods. From the Osservatorio Epidemiologico Cardiovascolare sample, 6508 people aged 40-69 years without clinical manifestations of atherosclerosis were selected. Cardiovascular risk was assessed using risk chart and individual risk score and the 10-year risk was categorized in six classes (<5%, 5-9%, 10-14%, 15-19%, 20-29%, ≥ 30 %). As coefficient of agreement between risk chart and individual risk score, Cohen kappa statistic was computed using the Ciechetti-Allison weights (kw). Results. From contingency tables of the two methods distribution, kw was 0.71 (p <0.0001 and 95% confidence interval 0.70-0.72). Using the 20% risk threshold reported in Nota 13 of Agenzia Italiana del Farmaco and excluding persons who were treated for hyperlipemia refunded regardless of their chart or individual score estimation of cardiovascular risk, the differences between the two tools classification resulted in the 2.6% of the sample (1.4% were assessed as at non-high risk [<20%] using the risk chart and at high risk using the individual risk score, and the opposite for 1.2%). Conclusions. Classification difference between risk charts and the individual risk score is quite small. Updating of predictive functions of two tools could improve their concordance also for individual evaluation, including older people and better reflecting current Italian lifestyle.

Translated title of the contributionAssestment of the absolute global cardiovascular risk: Comparison betweeen the risk chart and the individual score of the CUORE Project
Original languageItalian
Pages (from-to)359-364
Number of pages6
JournalGiornale Italiano di Cardiologia
Volume7
Issue number5
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Giampaoli, S., Palmieri, L., Donfrancesco, C., Panico, S., Pilotto, L., Addis, A., Boccanelli, A., Di Pasquale, G., Brignoli, O., Filippi, A., Vanuzzo, D., Dima, F., Lo Noce, C., Palmieri, L., Trojam, M., Valagussa, F., Pede, S., Uguccioni, M., Riccio, C., ... Budini, A. (2006). La valutazione del rischio cardiovascolare globale assoluto: Confronto tra carta e punteggio del Progetto CUORE. Giornale Italiano di Cardiologia, 7(5), 359-364.