Assignment of human coagulation factor XII (fXII) to chromosome 5 by cDNA hybridization to DNA from somatic cell hybrids

F. Citarella, M. Tripodi, A. Fantoni, F. Bernardi, G. Romeo, M. Rocchi

Research output: Contribution to journalArticle

Abstract

Human coagulation factor XII (fXII), a serine protease synthesized in liver and active in plasma, is involved in a wide variety of functions, including blood coagulation, fibrinolysis, bradykinin and complement activation. A complementary DNA (597 bp) encoding amino acid-16 to amino acid 183 of fXII protein was used to determine the chromosomal location of the fXII gene. DNAs from hamster-human somatic cell hybrids were digested with restriction enzymes and hybridized with the fXII cDNA. By the Southern method it was shown that restriction fragments able to hybridize to fXII cDNA are present only in DNA extracted from clones retaining human chromosome 5.

Original languageEnglish
Pages (from-to)397-398
Number of pages2
JournalHuman Genetics
Volume80
Issue number4
DOIs
Publication statusPublished - Dec 1988

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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