Assisted reproduction treatment in severe myasthenia gravis

Giuseppe Ricci, Michela De Santis, Gloria Pagnini, Leo Fischer Tamaro, Elena Giolo, Secondo Guaschino

Research output: Contribution to journalArticlepeer-review


Objective: To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception. Design: Case report and literature review. Setting: Tertiary infertility center. Patient(s): A 40-year-old woman affected by severe MG. Intervention(s): Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia. Main Outcome Measure(s): Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG. Result(s): A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed. Conclusion(s): This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART.

Original languageEnglish
JournalFertility and Sterility
Issue number3
Publication statusPublished - Sep 2008


  • Assisted reproduction treatment
  • autoimmunity
  • controlled ovarian hyperstimulation
  • estrogens
  • myasthenia gravis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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