Assisted reproduction treatment in severe myasthenia gravis

Giuseppe Ricci, Michela De Santis, Gloria Pagnini, Leo Fischer Tamaro, Elena Giolo, Secondo Guaschino

Research output: Contribution to journalArticle

Abstract

Objective: To report a case of a patient with a severe myasthenia gravis (MG) who underwent controlled ovarian hyperstimulation for assisted conception. Design: Case report and literature review. Setting: Tertiary infertility center. Patient(s): A 40-year-old woman affected by severe MG. Intervention(s): Controlled ovarian hyperstimulation, oocyte retrieval, intracytoplasmic sperm injection (ICSI) procedure for severe oligoastenozoospermia. Main Outcome Measure(s): Short- and long-term effects of assisted reproduction treatment (ART) on the clinical course of MG. Result(s): A total of four ICSI cycles were performed. In the third cycle, a pregnancy was achieved, but a spontaneous abortion occurred. No changes in MG therapy were necessary, neither before nor after the treatment. All procedures were well tolerated and no exacerbations of symptoms occurred. By contrast a little, but persistent, improvement of clinical disease course was observed. Conclusion(s): This is the first report of a patient with severe MG who underwent ART cycles. Although more patients need to be evaluated, the present case suggests that MG patients should not be excluded a priori from ART.

Original languageEnglish
JournalFertility and Sterility
Volume90
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Myasthenia Gravis
Reproduction
Intracytoplasmic Sperm Injections
Therapeutics
Oocyte Retrieval
Spontaneous Abortion
Infertility
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Assisted reproduction treatment
  • autoimmunity
  • controlled ovarian hyperstimulation
  • estrogens
  • myasthenia gravis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Assisted reproduction treatment in severe myasthenia gravis. / Ricci, Giuseppe; De Santis, Michela; Pagnini, Gloria; Tamaro, Leo Fischer; Giolo, Elena; Guaschino, Secondo.

In: Fertility and Sterility, Vol. 90, No. 3, 09.2008.

Research output: Contribution to journalArticle

Ricci, Giuseppe ; De Santis, Michela ; Pagnini, Gloria ; Tamaro, Leo Fischer ; Giolo, Elena ; Guaschino, Secondo. / Assisted reproduction treatment in severe myasthenia gravis. In: Fertility and Sterility. 2008 ; Vol. 90, No. 3.
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