Associated cancers in Waldenström macroglobulinemia: Clues for common genetic predisposition

Enrica Morra, Marzia Varettoni, Alessandra Tedeschi, Luca Arcaini, Francesca Ricci, Cristiana Pascutto, Sara Rattotti, Eleonora Vismara, Laura Paris, Mario Cazzola

Research output: Contribution to journalArticlepeer-review


Background Several population-based and cohort studies have reported an increased risk of second cancers in lymphoproliferative disorders (LPDs). The cause of second cancers in LPDs is probably multifactorial, and the relative contribution of treatments, genetic predisposition, and immune dysfunction typical of LPDs is still unclear. Patients and Methods We retrospectively studied 230 patients with Waldenström macroglobulinemia (WM) to assess the frequency, characteristics, and predictive factors of second cancers and to evaluate whether patients with WM are at higher risk of second cancers compared with an age- and sex-matched control population. Results In a competing-risk model, the cumulative incidence of solid cancers was 6% at 5 years, 11% at 10 years, and 17% at 15 years, whereas the incidence of hematologic malignancies was 4% at 5 years, 7% at 10 years, and 8% at 15 years. Compared with an age- and sex-matched population, the overall risk of second cancers was 1.7-fold higher than expected (95% confidence interval [CI], 1.22-2.38; P =.002). Patients with WM were at increased risk for diffuse large B-cell lymphoma (DLBCL) (standardized incidence ratio [SIR], 8.64; 95% CI, 3.88-19.22; P

Original languageEnglish
Pages (from-to)700-703
Number of pages4
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number6
Publication statusPublished - Dec 2013


  • Hematologic malignancies
  • Second cancers
  • Solid tumors
  • Waldenström macroglobulinemia

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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