Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

Ruyi Huang; Yongyue Wei; Rayjean J. Hung; Geoffrey Liu; Li Su; Ruyang Zhang; Xuchen Zong; Zuo Feng Zhang; Hal Morgenstern; Irene Brüske; Joachim Heinrich; Yun Chul Hong; Jin Hee Kim; Michele Cote; Angela Wenzlaff; Ann G. Schwartz; Isabelle Stucker; John Mclaughlin; Michael W. Marcus; Michael P A Davies; Triantafillos Liloglou; John K. Field; Keitaro Matsuo; Matt Barnett; Mark Thornquist; Gary Goodman; Yi Wang; Size Chen; Ping Yang; Eric J. Duell; Angeline S. Andrew; Philip Lazarus; Joshua Muscat; Penella Woll; Janet Horsman; M. Dawn Teare; Anath Flugelman; Gad Rennert; Yan Zhang; Hermann Brenner; Christa Stegmaier; Erik H F M van der Heijden; Katja Aben; Lambertus Kiemeney; Juan Barros-Dios; Monica Pérez-Ríos; Alberto Ruano-Ravina; Neil E. Caporaso; Pier Alberto Bertazzi; Maria Teresa Landi; Juncheng Dai; Hongbing Shen; Guillermo Fernandez-Tardon; Marta Rodriguez-Suarez; Adonina Tardon; David C. Christiani

doi:10.1016/j.ebiom.2015.09.031

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

Ruyi Huang, Yongyue Wei, Rayjean J. Hung, Geoffrey Liu, Li Su, Ruyang Zhang, Xuchen Zong, Zuo Feng Zhang, Hal Morgenstern, Irene Brüske, Joachim Heinrich, Yun Chul Hong, Jin Hee Kim, Michele Cote, Angela Wenzlaff, Ann G. Schwartz, Isabelle Stucker, John Mclaughlin, Michael W. Marcus, Michael P A DaviesTriantafillos Liloglou, John K. Field, Keitaro Matsuo, Matt Barnett, Mark Thornquist, Gary Goodman, Yi Wang, Size Chen, Ping Yang, Eric J. Duell, Angeline S. Andrew, Philip Lazarus, Joshua Muscat, Penella Woll, Janet Horsman, M. Dawn Teare, Anath Flugelman, Gad Rennert, Yan Zhang, Hermann Brenner, Christa Stegmaier, Erik H F M van der Heijden, Katja Aben, Lambertus Kiemeney, Juan Barros-Dios, Monica Pérez-Ríos, Alberto Ruano-Ravina, Neil E. Caporaso, Pier Alberto Bertazzi, Maria Teresa Landi, Juncheng Dai, Hongbing Shen, Guillermo Fernandez-Tardon, Marta Rodriguez-Suarez, Adonina Tardon, David C. Christiani

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%_{quit_for_5-9 years} to 89%_{quit_for_≥20 years} declined SCLC risk vs. subjectswho had quit smoking

Original language	English
Pages (from-to)	1677-1685
Number of pages	9
Journal	EBioMedicine
Volume	2
Issue number	11
DOIs	https://doi.org/10.1016/j.ebiom.2015.09.031
Publication status	Published - Nov 1 2015

Keywords

Causal mediation analysis
Chronic obstructive pulmonary disease
Multicenter pooling
Small cell lung cancer risk
Smoking behaviors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Huang, R., Wei, Y., Hung, R. J., Liu, G., Su, L., Zhang, R., Zong, X., Zhang, Z. F., Morgenstern, H., Brüske, I., Heinrich, J., Hong, Y. C., Kim, J. H., Cote, M., Wenzlaff, A., Schwartz, A. G., Stucker, I., Mclaughlin, J., Marcus, M. W., ... Christiani, D. C. (2015). Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium. EBioMedicine, 2(11), 1677-1685. https://doi.org/10.1016/j.ebiom.2015.09.031

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer : A Pooled Analysis in the International Lung Cancer Consortium. / Huang, Ruyi; Wei, Yongyue; Hung, Rayjean J.; Liu, Geoffrey; Su, Li; Zhang, Ruyang; Zong, Xuchen; Zhang, Zuo Feng; Morgenstern, Hal; Brüske, Irene; Heinrich, Joachim; Hong, Yun Chul; Kim, Jin Hee; Cote, Michele; Wenzlaff, Angela; Schwartz, Ann G.; Stucker, Isabelle; Mclaughlin, John; Marcus, Michael W.; Davies, Michael P A; Liloglou, Triantafillos; Field, John K.; Matsuo, Keitaro; Barnett, Matt; Thornquist, Mark; Goodman, Gary; Wang, Yi; Chen, Size; Yang, Ping; Duell, Eric J.; Andrew, Angeline S.; Lazarus, Philip; Muscat, Joshua; Woll, Penella; Horsman, Janet; Dawn Teare, M.; Flugelman, Anath; Rennert, Gad; Zhang, Yan; Brenner, Hermann; Stegmaier, Christa; van der Heijden, Erik H F M; Aben, Katja; Kiemeney, Lambertus; Barros-Dios, Juan; Pérez-Ríos, Monica; Ruano-Ravina, Alberto; Caporaso, Neil E.; Bertazzi, Pier Alberto; Landi, Maria Teresa; Dai, Juncheng; Shen, Hongbing; Fernandez-Tardon, Guillermo; Rodriguez-Suarez, Marta; Tardon, Adonina; Christiani, David C.

In: EBioMedicine, Vol. 2, No. 11, 01.11.2015, p. 1677-1685.

Research output: Contribution to journal › Article

Huang, R, Wei, Y, Hung, RJ, Liu, G, Su, L, Zhang, R, Zong, X, Zhang, ZF, Morgenstern, H, Brüske, I, Heinrich, J, Hong, YC, Kim, JH, Cote, M, Wenzlaff, A, Schwartz, AG, Stucker, I, Mclaughlin, J, Marcus, MW, Davies, MPA, Liloglou, T, Field, JK, Matsuo, K, Barnett, M, Thornquist, M, Goodman, G, Wang, Y, Chen, S, Yang, P, Duell, EJ, Andrew, AS, Lazarus, P, Muscat, J, Woll, P, Horsman, J, Dawn Teare, M, Flugelman, A, Rennert, G, Zhang, Y, Brenner, H, Stegmaier, C, van der Heijden, EHFM, Aben, K, Kiemeney, L, Barros-Dios, J, Pérez-Ríos, M, Ruano-Ravina, A, Caporaso, NE, Bertazzi, PA, Landi, MT, Dai, J, Shen, H, Fernandez-Tardon, G, Rodriguez-Suarez, M, Tardon, A & Christiani, DC 2015, 'Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium', EBioMedicine, vol. 2, no. 11, pp. 1677-1685. https://doi.org/10.1016/j.ebiom.2015.09.031

Huang, Ruyi ; Wei, Yongyue ; Hung, Rayjean J. ; Liu, Geoffrey ; Su, Li ; Zhang, Ruyang ; Zong, Xuchen ; Zhang, Zuo Feng ; Morgenstern, Hal ; Brüske, Irene ; Heinrich, Joachim ; Hong, Yun Chul ; Kim, Jin Hee ; Cote, Michele ; Wenzlaff, Angela ; Schwartz, Ann G. ; Stucker, Isabelle ; Mclaughlin, John ; Marcus, Michael W. ; Davies, Michael P A ; Liloglou, Triantafillos ; Field, John K. ; Matsuo, Keitaro ; Barnett, Matt ; Thornquist, Mark ; Goodman, Gary ; Wang, Yi ; Chen, Size ; Yang, Ping ; Duell, Eric J. ; Andrew, Angeline S. ; Lazarus, Philip ; Muscat, Joshua ; Woll, Penella ; Horsman, Janet ; Dawn Teare, M. ; Flugelman, Anath ; Rennert, Gad ; Zhang, Yan ; Brenner, Hermann ; Stegmaier, Christa ; van der Heijden, Erik H F M ; Aben, Katja ; Kiemeney, Lambertus ; Barros-Dios, Juan ; Pérez-Ríos, Monica ; Ruano-Ravina, Alberto ; Caporaso, Neil E. ; Bertazzi, Pier Alberto ; Landi, Maria Teresa ; Dai, Juncheng ; Shen, Hongbing ; Fernandez-Tardon, Guillermo ; Rodriguez-Suarez, Marta ; Tardon, Adonina ; Christiani, David C. / Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer : A Pooled Analysis in the International Lung Cancer Consortium. In: EBioMedicine. 2015 ; Vol. 2, No. 11. pp. 1677-1685.

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title = "Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium",

abstract = "Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_≥20 years declined SCLC risk vs. subjectswho had quit smoking ",

keywords = "Causal mediation analysis, Chronic obstructive pulmonary disease, Multicenter pooling, Small cell lung cancer risk, Smoking behaviors",

author = "Ruyi Huang and Yongyue Wei and Hung, {Rayjean J.} and Geoffrey Liu and Li Su and Ruyang Zhang and Xuchen Zong and Zhang, {Zuo Feng} and Hal Morgenstern and Irene Br{\"u}ske and Joachim Heinrich and Hong, {Yun Chul} and Kim, {Jin Hee} and Michele Cote and Angela Wenzlaff and Schwartz, {Ann G.} and Isabelle Stucker and John Mclaughlin and Marcus, {Michael W.} and Davies, {Michael P A} and Triantafillos Liloglou and Field, {John K.} and Keitaro Matsuo and Matt Barnett and Mark Thornquist and Gary Goodman and Yi Wang and Size Chen and Ping Yang and Duell, {Eric J.} and Andrew, {Angeline S.} and Philip Lazarus and Joshua Muscat and Penella Woll and Janet Horsman and {Dawn Teare}, M. and Anath Flugelman and Gad Rennert and Yan Zhang and Hermann Brenner and Christa Stegmaier and {van der Heijden}, {Erik H F M} and Katja Aben and Lambertus Kiemeney and Juan Barros-Dios and Monica P{\'e}rez-R{\'i}os and Alberto Ruano-Ravina and Caporaso, {Neil E.} and Bertazzi, {Pier Alberto} and Landi, {Maria Teresa} and Juncheng Dai and Hongbing Shen and Guillermo Fernandez-Tardon and Marta Rodriguez-Suarez and Adonina Tardon and Christiani, {David C.}",

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T1 - Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer

T2 - A Pooled Analysis in the International Lung Cancer Consortium

AU - Huang, Ruyi

AU - Wei, Yongyue

AU - Hung, Rayjean J.

AU - Liu, Geoffrey

AU - Su, Li

AU - Zhang, Ruyang

AU - Zong, Xuchen

AU - Zhang, Zuo Feng

AU - Morgenstern, Hal

AU - Brüske, Irene

AU - Heinrich, Joachim

AU - Hong, Yun Chul

AU - Kim, Jin Hee

AU - Cote, Michele

AU - Wenzlaff, Angela

AU - Schwartz, Ann G.

AU - Stucker, Isabelle

AU - Mclaughlin, John

AU - Marcus, Michael W.

AU - Davies, Michael P A

AU - Liloglou, Triantafillos

AU - Field, John K.

AU - Matsuo, Keitaro

AU - Barnett, Matt

AU - Thornquist, Mark

AU - Goodman, Gary

AU - Wang, Yi

AU - Chen, Size

AU - Yang, Ping

AU - Duell, Eric J.

AU - Andrew, Angeline S.

AU - Lazarus, Philip

AU - Muscat, Joshua

AU - Woll, Penella

AU - Horsman, Janet

AU - Dawn Teare, M.

AU - Flugelman, Anath

AU - Rennert, Gad

AU - Zhang, Yan

AU - Brenner, Hermann

AU - Stegmaier, Christa

AU - van der Heijden, Erik H F M

AU - Aben, Katja

AU - Kiemeney, Lambertus

AU - Barros-Dios, Juan

AU - Pérez-Ríos, Monica

AU - Ruano-Ravina, Alberto

AU - Caporaso, Neil E.

AU - Bertazzi, Pier Alberto

AU - Landi, Maria Teresa

AU - Dai, Juncheng

AU - Shen, Hongbing

AU - Fernandez-Tardon, Guillermo

AU - Rodriguez-Suarez, Marta

AU - Tardon, Adonina

AU - Christiani, David C.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_≥20 years declined SCLC risk vs. subjectswho had quit smoking

AB - Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_≥20 years declined SCLC risk vs. subjectswho had quit smoking

KW - Causal mediation analysis

KW - Chronic obstructive pulmonary disease

KW - Multicenter pooling

KW - Small cell lung cancer risk

KW - Smoking behaviors

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