Abstract
Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_≥20 years declined SCLC risk vs. subjectswho had quit smoking
Original language | English |
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Pages (from-to) | 1677-1685 |
Number of pages | 9 |
Journal | EBioMedicine |
Volume | 2 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2015 |
Keywords
- Causal mediation analysis
- Chronic obstructive pulmonary disease
- Multicenter pooling
- Small cell lung cancer risk
- Smoking behaviors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)