TY - JOUR
T1 - Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms
AU - Orlacchio, Antonio
AU - Kawarai, Toshitaka
AU - Polidoro, Mario
AU - Stefani, Alessandro
AU - Orlacchio, Aldo
AU - St George-Hyslop, Peter H.
AU - Bernardi, Giorgio
PY - 2002/11/22
Y1 - 2002/11/22
N2 - The biological study of the Nicastrin protein shows its crucial role in the pathogenesis of Alzheimer's disease (AD). We tested the hypothesis that the Nicastrin (NCSTN) gene might be genetically associated with AD. The association analysis of two single nucleotide polymorphisms (SNPs) in the coding region (cSNPs) of NCSTN were performed in an Italian population. No evidence of association was obtained between the two SNPs investigated in sporadic and familial AD cases under the stratification of currently known genetic risk factors including the apolipoprotein E (APOE), the presenilins and the β-amyloid precursor protein. The result suggests no apparent synergic interaction between the NCSTN and APOE ε4 in the risk to develop the late onset sporadic form of AD. But considering its biological effects, the result can not exclude the NCSTN as candidate for genetic factor in AD. Further genetic study of the NCSTN would be necessary to evaluate the potential genetic involvement in AD.
AB - The biological study of the Nicastrin protein shows its crucial role in the pathogenesis of Alzheimer's disease (AD). We tested the hypothesis that the Nicastrin (NCSTN) gene might be genetically associated with AD. The association analysis of two single nucleotide polymorphisms (SNPs) in the coding region (cSNPs) of NCSTN were performed in an Italian population. No evidence of association was obtained between the two SNPs investigated in sporadic and familial AD cases under the stratification of currently known genetic risk factors including the apolipoprotein E (APOE), the presenilins and the β-amyloid precursor protein. The result suggests no apparent synergic interaction between the NCSTN and APOE ε4 in the risk to develop the late onset sporadic form of AD. But considering its biological effects, the result can not exclude the NCSTN as candidate for genetic factor in AD. Further genetic study of the NCSTN would be necessary to evaluate the potential genetic involvement in AD.
KW - Alzheimer's disease
KW - Nicastrin gene
KW - Single nucleotide polymorphisms
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U2 - 10.1016/S0304-3940(02)01022-4
DO - 10.1016/S0304-3940(02)01022-4
M3 - Article
C2 - 12419494
AN - SCOPUS:0037159588
VL - 333
SP - 115
EP - 118
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -