Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. FrenchXiao Qing Chen, Laura Fachal, Karen McCue, Amy E.Mc Cart Reed, Maya Ghoussaini, Jason S. Carroll, Xia Jiang, Hilary Finucane, Marcia Adams, Muriel A. Adank, Habibul Ahsan, Kristiina Aittomäki, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Banu Arun, Paul L. Auer, François Bacot, Myrto Barrdahl, Caroline Baynes, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bernardo Bonanni, Siranoush Manoukian, Paolo Radice, NBCS Collaborators, ABCTB Investigators, kConFab/AOCS Investigators

Research output: Contribution to journalArticle

Abstract

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

Original languageEnglish
Pages (from-to)92-94
Number of pages3
JournalNature
Volume551
Issue number7678
DOIs
Publication statusPublished - Nov 2 2017

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Breast Neoplasms
Genes
Single Nucleotide Polymorphism
Genome-Wide Association Study
Genetic Predisposition to Disease
Computer Simulation
Breast
Transcription Factors
Binding Sites
Genome

ASJC Scopus subject areas

  • General

Cite this

Michailidou, K., Lindström, S., Dennis, J., Beesley, J., Hui, S., Kar, S., ... kConFab/AOCS Investigators (2017). Association analysis identifies 65 new breast cancer risk loci. Nature, 551(7678), 92-94. https://doi.org/10.1038/nature24284

Association analysis identifies 65 new breast cancer risk loci. / Michailidou, Kyriaki; Lindström, Sara; Dennis, Joe; Beesley, Jonathan; Hui, Shirley; Kar, Siddhartha; Lemaçon, Audrey; Soucy, Penny; Glubb, Dylan; Rostamianfar, Asha; Bolla, Manjeet K.; Wang, Qin; Tyrer, Jonathan; Dicks, Ed; Lee, Andrew; Wang, Zhaoming; Allen, Jamie; Keeman, Renske; Eilber, Ursula; French, Juliet D.; Chen, Xiao Qing; Fachal, Laura; McCue, Karen; Reed, Amy E.Mc Cart; Ghoussaini, Maya; Carroll, Jason S.; Jiang, Xia; Finucane, Hilary; Adams, Marcia; Adank, Muriel A.; Ahsan, Habibul; Aittomäki, Kristiina; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Arun, Banu; Auer, Paul L.; Bacot, François; Barrdahl, Myrto; Baynes, Caroline; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bonanni, Bernardo; Manoukian, Siranoush; Radice, Paolo; NBCS Collaborators; ABCTB Investigators; kConFab/AOCS Investigators.

In: Nature, Vol. 551, No. 7678, 02.11.2017, p. 92-94.

Research output: Contribution to journalArticle

Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, MK, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, JD, Chen, XQ, Fachal, L, McCue, K, Reed, AEMC, Ghoussaini, M, Carroll, JS, Jiang, X, Finucane, H, Adams, M, Adank, MA, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, NN, Arndt, V, Aronson, KJ, Arun, B, Auer, PL, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, MW, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Bonanni, B, Manoukian, S, Radice, P, NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators 2017, 'Association analysis identifies 65 new breast cancer risk loci', Nature, vol. 551, no. 7678, pp. 92-94. https://doi.org/10.1038/nature24284
Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S et al. Association analysis identifies 65 new breast cancer risk loci. Nature. 2017 Nov 2;551(7678):92-94. https://doi.org/10.1038/nature24284
Michailidou, Kyriaki ; Lindström, Sara ; Dennis, Joe ; Beesley, Jonathan ; Hui, Shirley ; Kar, Siddhartha ; Lemaçon, Audrey ; Soucy, Penny ; Glubb, Dylan ; Rostamianfar, Asha ; Bolla, Manjeet K. ; Wang, Qin ; Tyrer, Jonathan ; Dicks, Ed ; Lee, Andrew ; Wang, Zhaoming ; Allen, Jamie ; Keeman, Renske ; Eilber, Ursula ; French, Juliet D. ; Chen, Xiao Qing ; Fachal, Laura ; McCue, Karen ; Reed, Amy E.Mc Cart ; Ghoussaini, Maya ; Carroll, Jason S. ; Jiang, Xia ; Finucane, Hilary ; Adams, Marcia ; Adank, Muriel A. ; Ahsan, Habibul ; Aittomäki, Kristiina ; Anton-Culver, Hoda ; Antonenkova, Natalia N. ; Arndt, Volker ; Aronson, Kristan J. ; Arun, Banu ; Auer, Paul L. ; Bacot, François ; Barrdahl, Myrto ; Baynes, Caroline ; Beckmann, Matthias W. ; Behrens, Sabine ; Benitez, Javier ; Bermisheva, Marina ; Bernstein, Leslie ; Blomqvist, Carl ; Bonanni, Bernardo ; Manoukian, Siranoush ; Radice, Paolo ; NBCS Collaborators ; ABCTB Investigators ; kConFab/AOCS Investigators. / Association analysis identifies 65 new breast cancer risk loci. In: Nature. 2017 ; Vol. 551, No. 7678. pp. 92-94.
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