Abstract
This study investigated the tumor necrosis factor-α gene (TNFA; -238 G/A and -308 G/A polymorphisms) on the development of schizophrenia, as well as the interaction of the two polymorphisms in relation to symptomatology, family history, onset age and antipsychotic treatment response. Genomic DNA analyses with polymerase chain reaction (PCR) were used for the genotyping. One hundred and fifty-two (152) patients with schizophrenia and 152 normal controls participated in the study. Any associations between the individual polymorphism and schizophrenia were not found. However, marginal association between subjects with TNFA -238 A allele (genotype AA plus AG) and presence of family history was found (p=0.023). No significant interaction effects between TNFA -238 and -308 polymorphisms either on the development of schizophrenia or on clinical variables such as antipsychotics treatment response and psychopathology were found, although a significant interaction effect for subjects carrying TNFA -238 AG and -308 AA genotypes on a positive family history was observed (p=0.017). These results suggest that the interaction effects between TNFA -238 and -308 polymorphisms gives no significant contribution to the susceptibility to schizophrenia, and is not associated with clinical variables, antipsychotic treatment response and psychopathological features, except for family history of disease, at least in Korean population.
| Original language | English |
|---|---|
| Pages (from-to) | 152-157 |
| Number of pages | 6 |
| Journal | Gene Therapy and Molecular Biology |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - 2009 |
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Keywords
- Clinical variables
- Schizophrenia
- Tumor necrosis factor-αgene
ASJC Scopus subject areas
- Molecular Biology
- Molecular Medicine
Cite this
Association analysis of the tumor necrosis factor gene polymorphisms (TNFA 238 and 302) in the development of schizophrenia : Impact on the antipsychotic treatment response. / Pae, Chi Un; Drago, Antonio; Chiesa, Alberto; Mandelli, Laura; Serretti, Alessandro; Jun, Tae Youn.
In: Gene Therapy and Molecular Biology, Vol. 13, No. 1, 2009, p. 152-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association analysis of the tumor necrosis factor gene polymorphisms (TNFA 238 and 302) in the development of schizophrenia
T2 - Impact on the antipsychotic treatment response
AU - Pae, Chi Un
AU - Drago, Antonio
AU - Chiesa, Alberto
AU - Mandelli, Laura
AU - Serretti, Alessandro
AU - Jun, Tae Youn
PY - 2009
Y1 - 2009
N2 - This study investigated the tumor necrosis factor-α gene (TNFA; -238 G/A and -308 G/A polymorphisms) on the development of schizophrenia, as well as the interaction of the two polymorphisms in relation to symptomatology, family history, onset age and antipsychotic treatment response. Genomic DNA analyses with polymerase chain reaction (PCR) were used for the genotyping. One hundred and fifty-two (152) patients with schizophrenia and 152 normal controls participated in the study. Any associations between the individual polymorphism and schizophrenia were not found. However, marginal association between subjects with TNFA -238 A allele (genotype AA plus AG) and presence of family history was found (p=0.023). No significant interaction effects between TNFA -238 and -308 polymorphisms either on the development of schizophrenia or on clinical variables such as antipsychotics treatment response and psychopathology were found, although a significant interaction effect for subjects carrying TNFA -238 AG and -308 AA genotypes on a positive family history was observed (p=0.017). These results suggest that the interaction effects between TNFA -238 and -308 polymorphisms gives no significant contribution to the susceptibility to schizophrenia, and is not associated with clinical variables, antipsychotic treatment response and psychopathological features, except for family history of disease, at least in Korean population.
AB - This study investigated the tumor necrosis factor-α gene (TNFA; -238 G/A and -308 G/A polymorphisms) on the development of schizophrenia, as well as the interaction of the two polymorphisms in relation to symptomatology, family history, onset age and antipsychotic treatment response. Genomic DNA analyses with polymerase chain reaction (PCR) were used for the genotyping. One hundred and fifty-two (152) patients with schizophrenia and 152 normal controls participated in the study. Any associations between the individual polymorphism and schizophrenia were not found. However, marginal association between subjects with TNFA -238 A allele (genotype AA plus AG) and presence of family history was found (p=0.023). No significant interaction effects between TNFA -238 and -308 polymorphisms either on the development of schizophrenia or on clinical variables such as antipsychotics treatment response and psychopathology were found, although a significant interaction effect for subjects carrying TNFA -238 AG and -308 AA genotypes on a positive family history was observed (p=0.017). These results suggest that the interaction effects between TNFA -238 and -308 polymorphisms gives no significant contribution to the susceptibility to schizophrenia, and is not associated with clinical variables, antipsychotic treatment response and psychopathological features, except for family history of disease, at least in Korean population.
KW - Clinical variables
KW - Schizophrenia
KW - Tumor necrosis factor-αgene
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UR - http://www.scopus.com/inward/citedby.url?scp=77649317332&partnerID=8YFLogxK
M3 - Article
VL - 13
SP - 152
EP - 157
JO - Gene Therapy and Molecular Biology
JF - Gene Therapy and Molecular Biology
SN - 1529-9120
IS - 1
ER -