Association between arterial properties and renal sodium handling in a general population

Jitka Seidlerová, Jan A. Staessen, Marc Maillard, Tim Nawrot, Haifeng Zhang, Murielle Bochud, Tatiana Kuznetsova, Tom Richart, Luc M. Van Bortel, Harry A. Struijker-Boudier, Paolo Manunta, Michel Burnier, Robert Fagard, Jan Filipovský

Research output: Contribution to journalArticle

Abstract

Mean arterial pressure drives pressure-natriuresis and determines arterial structure and function. In a population sample, we investigated the relation between arterial characteristics and renal sodium handling as assessed by the clearance of endogenous lithium. We ultrasonographically measured diameter, cross-sectional compliance (CC) and distensibility (DC) of the carotid, brachial, and femoral arteries in 1069 untreated subjects (mean age: 41.6 years; 50.1% women; 18.8% hypertensive subjects). While accounting for covariates and standardizing for the sodium excretion rate in both sexes, CC and DC of the femoral artery increased with higher fractional distal sodium reabsorption. Differences associated with a 1-SD change in fractional distal reabsorption of sodium were 51.7 mm/kPa×10 (95% CI: 23.9 to 79.5; P=0.0002) and 0.56×10/kPa (95% CI: 0.17 to 0.94; P=0.004) for femoral CC and DC, respectively. In women as well as in men, a 1-SD increment in fractional proximal sodium reabsorption was associated with decreases in femoral and brachial diameter, amounting to 111.6 μm (95% CI: 38.2 to 185.1; P=0.003) and 52.5 μm (95% CI: 10.0 to 94.9; P=0.016), respectively. There was no consistent association between the properties of the elastic carotid artery and renal sodium handling. In conclusion, higher fractional sodium reabsorption in the distal nephron is associated with higher femoral CC and DC, and higher proximal sodium reabsorption is associated with decreased brachial and femoral diameters. These findings demonstrate that there might be an influence of renal sodium handling on arterial properties or vice versa or that common mechanisms might influence both arterial and renal function.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalHypertension
Volume48
Issue number4
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Sodium
Kidney
Population
Thigh
Compliance
Femoral Artery
Carotid Arteries
Arm
Natriuresis
Brachial Artery
Nephrons
Lithium
Arterial Pressure
Pressure

Keywords

  • Arterial distensibility
  • Arterial stiffness
  • Pressure-natriuresis
  • Renal sodium handling

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Seidlerová, J., Staessen, J. A., Maillard, M., Nawrot, T., Zhang, H., Bochud, M., ... Filipovský, J. (2006). Association between arterial properties and renal sodium handling in a general population. Hypertension, 48(4), 609-615. https://doi.org/10.1161/01.HYP.0000240516.60040.ba

Association between arterial properties and renal sodium handling in a general population. / Seidlerová, Jitka; Staessen, Jan A.; Maillard, Marc; Nawrot, Tim; Zhang, Haifeng; Bochud, Murielle; Kuznetsova, Tatiana; Richart, Tom; Van Bortel, Luc M.; Struijker-Boudier, Harry A.; Manunta, Paolo; Burnier, Michel; Fagard, Robert; Filipovský, Jan.

In: Hypertension, Vol. 48, No. 4, 10.2006, p. 609-615.

Research output: Contribution to journalArticle

Seidlerová, J, Staessen, JA, Maillard, M, Nawrot, T, Zhang, H, Bochud, M, Kuznetsova, T, Richart, T, Van Bortel, LM, Struijker-Boudier, HA, Manunta, P, Burnier, M, Fagard, R & Filipovský, J 2006, 'Association between arterial properties and renal sodium handling in a general population', Hypertension, vol. 48, no. 4, pp. 609-615. https://doi.org/10.1161/01.HYP.0000240516.60040.ba
Seidlerová J, Staessen JA, Maillard M, Nawrot T, Zhang H, Bochud M et al. Association between arterial properties and renal sodium handling in a general population. Hypertension. 2006 Oct;48(4):609-615. https://doi.org/10.1161/01.HYP.0000240516.60040.ba
Seidlerová, Jitka ; Staessen, Jan A. ; Maillard, Marc ; Nawrot, Tim ; Zhang, Haifeng ; Bochud, Murielle ; Kuznetsova, Tatiana ; Richart, Tom ; Van Bortel, Luc M. ; Struijker-Boudier, Harry A. ; Manunta, Paolo ; Burnier, Michel ; Fagard, Robert ; Filipovský, Jan. / Association between arterial properties and renal sodium handling in a general population. In: Hypertension. 2006 ; Vol. 48, No. 4. pp. 609-615.
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