TY - JOUR
T1 - Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma
T2 - A case–control study and epidemiological remarks
AU - ReNaM Working Group
AU - Marinaccio, Alessandro
AU - Consonni, Dario
AU - Mensi, Carolina
AU - Mirabelli, Dario
AU - Migliore, Enrica
AU - Magnani, Corrado
AU - Di Marzio, Davide
AU - Gennaro, Valerio
AU - Mazzoleni, Guido
AU - Girardi, Paolo
AU - Negro, Corrado
AU - Romanelli, Antonio
AU - Chellini, Elisabetta
AU - Grappasonni, Iolanda
AU - Madeo, Gabriella
AU - Romeo, Elisa
AU - Ascoli, Valeria
AU - Carrozza, Francesco
AU - Angelillo, Italo Francesco
AU - Cavone, Domenica
AU - Tumino, Rosario
AU - Melis, Massimo
AU - Curti, Stefania
AU - Brandi, Giovanni
AU - Mattioli, Stefano
AU - Iavicoli, Sergio
AU - Dallari, Barbara
AU - Pesatori, Angela Cecilia
AU - Riboldi, Luciano
AU - Merletti, Franco
AU - Gangemi, Manuela
AU - Stura, Antonella
AU - Brentisci, Carol
AU - Gilardetti, Marco
AU - Benfatto, Lucia
AU - Canessa, Pier Aldo
AU - Malacarne, Davide
AU - Mazzucco, Giovanna
AU - Campi, Maria Giuseppina
AU - Fedeli, Ugo
AU - Bressan, Vittoria
AU - Gioffrè, Francesco
AU - Ballarin, Maria Nicoletta
AU - Chermaz, Carol
AU - D’agostin, Flavia
AU - De Michieli, Paola
AU - Mangone, Lucia
AU - Storchi, Cinzia
AU - Martini, Andrea
AU - Stecchi, Sergio
N1 - Funding Information:
INAIL (Italian Workers Compensation Authority) partial supported and funded this work: research triennial plan of action 2016–2018, project BRIC n.59. The units of epidemiology or occupational health hosting the COR belong to the National Health Service and are financed
Publisher Copyright:
© 2020, Nordic Association of Occupational Safety and Health. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objectives The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis meso-thelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
AB - Objectives The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis meso-thelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
KW - Epidemiology
KW - Italy
KW - National registry
KW - Rare disease
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U2 - 10.5271/sjweh.3895
DO - 10.5271/sjweh.3895
M3 - Article
C2 - 32253443
AN - SCOPUS:85090679806
VL - 46
SP - 609
EP - 617
JO - Scandinavian Journal of Work, Environment and Health
JF - Scandinavian Journal of Work, Environment and Health
SN - 0355-3140
IS - 6
ER -