Association between baseline tumour burden and outcome in patients with cancer treated with next-generation immunoncology agents

Paolo Tarantino, Antonio Marra, Sara Gandini, Marta Minotti, Paola Pricolo, Giulia Signorelli, Carmen Criscitiello, Marzia Locatelli, Carmen Belli, Massimo Bellomi, Giuseppe Curigliano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Baseline tumour burden is a prognostic factor for patients with melanoma and non–small-cell lung cancer treated with immunotherapy. However, no data are available on its role in other solid tumours, nor for treatment with next-generation immunoncology agents (NGIOs). Methods: We reviewed data of patients with any solid tumour consecutively treated at our institution from August 2014 to March 2019, who received ≥1 dose of immune checkpoint inhibitor and/or NGIO within phase 1 trials. Baseline tumour burden was calculated as ∑i Response Evaluation Criteria in Solid Tumours 1.1 baseline target lesions (baseline tumour size [BTS]) or as sum of all measurable baseline lesions (total tumour burden [TTB]); the impact of both parameters on treatment outcomes was investigated. Results: One hundred fifty patients were included in the analysis. Median BTS and TTB were 79 mm and 212 mm, respectively. Objective response rate was found significantly associated with BTS (p < 0.001) and TTB quartiles (p = 0.006), with response rates progressively increasing with decreasing tumour burden quartiles. Both progression-free survival (PFS) (p = 0.001) and overall survival (OS) (p < 0.001) were significantly associated with BTS quartiles, with 26% of the patients progression-free and 56% alive at 12 months in the lower BTS quartile, compared with 3% and 24%, respectively, in the upper quartile. TTB was also significantly associated with OS (P = 0.01) and borderline-significant for PFS (p = 0.07). Multivariate analysis confirmed that baseline burden, also considered as continuous variable, is independently associated with PFS and OS, when assessed with BTS (p = 0.001 and p < 0.001) and TTB (p = 0.007 and p < 0.001). Conclusions: Lower baseline tumour burden is associated with better outcomes in patients with cancer treated with novel immunotherapies.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalEuropean Journal of Cancer
Volume139
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Baseline tumour size
  • Immunotherapy
  • Next-generation immunoncology agents
  • Phase 1 trials
  • Total tumour burden

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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