Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu

Heather H. Burris, Joe M. Braun, Hyang Min Byun, Letizia Tarantini, Adriana Mercado, Rosalind J. Wright, Lourdes Schnaas, Andrea A. Baccarelli, Robert O. Wright, Martha M. Tellez-Rojo

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: We examined the association between birth weight and methylation in the imprinted IGF/H19 loci, the nonimprinted gene NR3C1 and repetitive element DNA (LINE-1 and Alu). Materials & methods: We collected umbilical cord venous blood from 219 infants born in Mexico City (Mexico) as part of a prospective birth cohort study and analyzed DNA methylation using pyrosequencing. Results: Birth weight was not associated with DNA methylation of the regions studied. One of the CpG dinucleotides in the IGF2 imprinting control region (ICR)1 includes a potential C-T SNP. Among individuals with an absence of methylation at this site, probably due to a paternally inherited T allele, birth weight was associated with mean methylation status of both IGF2 ICR1 and ICR2. However, this association would not have survived adjustment for multiple testing. Conclusion: While we did not detect an association between DNA methylation and birth weight, our study suggests a potential gene-epigene interaction between a T allele in the IGF2 ICR1 and methylation of ICRs of IGF2, and fetal growth.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalEpigenomics
Volume5
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Alu
  • birth weight
  • DNA methylation
  • fetal growth
  • glucocorticoid receptor
  • IGF2
  • imprinting
  • LINE-1
  • NR3C1
  • SNP

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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