Association between bone stiffness and nutritional biomarkers combined with weight-bearing exercise, physical activity, and sedentary time in preadolescent children. A case-control study

Diana Herrmann, Hermann Pohlabeln, Francesco Gianfagna, Kenn Konstabel, Lauren Lissner, Staffan Mårild, Dénes Molnar, Luis A. Moreno, Alfonso Siani, Isabelle Sioen, Toomas Veidebaum, Wolfgang Ahrens

Research output: Contribution to journalArticlepeer-review

Abstract

Physical activity (PA) and micronutrients such as calcium (Ca), vitamin D (25OHD), and phosphate (PO) are important determinants of skeletal development. This case-control study examined the association of these nutritional biomarkers and different PA behaviours, such as habitual PA, weight-bearing exercise (WBE) and sedentary time (SED) with bone stiffness (SI) in 1819 2-9-year-old children from the IDEFICS study (2007-2008). SI was measured on the calcaneus using quantitative ultrasound. Serum and urine Ca and PO and serum 25OHD were determined. Children's sports activities were reported by parents using a standardised questionnaire. A subsample of 1089 children had accelerometer-based PA data (counts per minute, cpm). Moderate-to-vigorous PA (MVPA) and SED were estimated. Children with poor SI (below the 15th age-/sex-/height-specific percentile) were defined as cases (N. =. 603). Randomly selected controls (N. =. 1216) were matched by age, sex, and country. Odds ratios (OR) for poor SI were calculated by conditional logistic regression for all biomarkers and PA behaviour variables separately and combined (expressed as tertiles and dichotomised variables, respectively). ORs were adjusted for fat-free mass, dairy product consumption, and daylight duration. We observed increased ORs for no sports (OR. =. 1.39, p.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalBone
Volume78
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Bone health
  • Bone stiffness
  • Case-control study
  • Epidemiology
  • Quantitative ultrasound
  • Weight-bearing exercise

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Fingerprint Dive into the research topics of 'Association between bone stiffness and nutritional biomarkers combined with weight-bearing exercise, physical activity, and sedentary time in preadolescent children. A case-control study'. Together they form a unique fingerprint.

Cite this