Association between cardiac autonomic dysfunction and inflammation in type 1 diabetic patients: Effect of beta-blockade

Gaetano Antono Lanza, Dario Pitocco, Eliano Pio Navarese, Alfonso Sestito, Gregory Angelo Sgueglia, Andrea Manto, Fabio Infusino, Tittania Musella, Giovanni Ghirlanda, Filippo Crea

Research output: Contribution to journalArticlepeer-review


Aims: To assess the relationship between cardiac autonomic dysfunction and inflammation in patients with type 1 diabetes and whether beta-blocker therapy might improve both abnormalities in these patients. Methods and results: We studied 49 patients with type 1 diabetes (age 50.5 ± 11 years, 33 men). Serum levels of high-sensitivity C-reactive protein, as a marker of inflammation, and frequency-domain heart rate variability (HRV) on 24 h Holter monitoring, as a measure of cardiac autonomic function, were assessed in all patients. Twenty-one patients with depressed HRV were subsequently randomized to receive atenolol (50 mg daily) or no-beta-blockade. HRV and C-reactive protein were re-assessed after 3-4 weeks from randomization. An inverse correlation was found between C-reactive protein levels and HRV parameters, with the highest r coefficient shown with low-frequency (LF) power (r = -0.38; P = 0.007). Furthermore, C-reactive protein serum levels were significantly higher in patients with bottom quartile values of LF power compared with patients with values in the three top quartiles (4.64 ± 2.8 vs.1.79 ± 1.6 mg/L, respectively; P = 0.003), also after adjustment for potential confounding variables (P = 0.013). HRV parameters improved significantly in patients treated with atenolol, but not in the no-atenolol group. Furthermore, C-reactive protein levels decreased in the beta-blockade group, but not in the no-beta-blockade group (P = 0.04 for changes between groups). Conclusion: In type 1 diabetic patients, serum C-reactive protein levels are significantly associated with depressed HRV; the favourable effects of beta-blockade on both HRV parameters and C-reactive protein serum levels suggest that autonomic nervous system may have significant modulator effects on inflammation.

Original languageEnglish
Pages (from-to)814-820
Number of pages7
JournalEuropean Heart Journal
Issue number7
Publication statusPublished - Apr 2007


  • C-reactive protein
  • Heart rate variability
  • Type 1 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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