Association between cigarette smoking and FHIT gene alterations in lung cancer

Gabriella Sozzi, Laura Sard, Laura De Gregorio, Antonio Marchetti, Katia Musso, Fiamma Buttitta, Silvana Tornielli, Silvia Pellegrini, Maria Luisa Veronese, Giacomo Manenti, Matteo Incarbone, Antonio Chella, Carlo A. Angeletti, Ugo Pastorino, Kay Huebner, Generoso Bevilaqua, Silvana Pilotti, Carlo M. Croce, Marco A. Pierotti

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiologic data have strongly indicated that cigarette smoking is linked to the development of lung cancer. However, little is known of the molecular targets of carcinogens contained in tobacco smoke. To identify genetic lesions characteristic of tobacco damage, we undertook a molecular analysis of microsatellite alterations within the FHIT gene and FRA3B, as well as at an independent locus on chromosome 10, D10S197, in lung tumors from heavy smokers and in tumors from never smokers. Loss of heterozygosity affecting at least one locus of the FHIT gene was observed in 41 of 51 tumors in the smokers group (80%) but in only 9 of 40 tumors in nonsmokers (22%). The comparison between the frequency of losses in FHIT in smokers and nonsmokers was statistically significant (P = 0.0001), whereas no difference in loss of heterozygosity rate was observed at D10S197 locus. These findings suggest that FHIT is a candidate molecular target of carcinogens contained in tobacco smoke.

Original languageEnglish
Pages (from-to)2121-2123
Number of pages3
JournalCancer Research
Volume57
Issue number11
Publication statusPublished - Jun 1 1997

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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