Abstract
AbstractBackground Although the association between multimorbidity and polypharmacy has been clearly documented, no study has analyzed whether or not specific combinations of diseases influence the prescription of polypharmacy in older persons. We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients. Methods This cross-sectional study was held in 38 Italian internal medicine and geriatric wards participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The study sample included 1155 in-patients aged 65 years or older. Clusters of diseases, defined as two or more co-occurring specific chronic diseases, were identified using the odds ratio (OR) for the associations between pairs of diseases followed by cluster analysis. Polypharmacy was defined as the prescription of five or more different medications at hospital discharge. Logistic regression models were run to analyze the association between clusters of diseases and polypharmacy. Results Among clusters of diseases, the highest mean number of drugs (> 8) was found in patients affected by heart failure (HF) plus chronic obstructive pulmonary disease (COPD), HF plus chronic renal failure (CRF), COPD plus coronary heart disease (CHD), diabetes mellitus plus CRF, and diabetes mellitus plus CHD plus cerebrovascular disease (CVD). The strongest association between clusters of diseases and polypharmacy was found for diabetes mellitus plus CHD plus CVD, diabetes plus CHD, and HF plus atrial fibrillation (AF). Conclusions The observed knowledge of the relationship among co-occurring diseases and polypharmacy should help to identify and monitor older in-patients at risk of polypharmacy.
| Original language | English |
|---|---|
| Pages (from-to) | 597-602 |
| Number of pages | 6 |
| Journal | European Journal of Internal Medicine |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2011 |
Fingerprint
Keywords
- Cluster of diseases
- Hospitalized elderly
- Polypharmacy
ASJC Scopus subject areas
- Internal Medicine
Cite this
Association between clusters of diseases and polypharmacy in hospitalized elderly patients : Results from the REPOSI study. / Nobili, Alessandro; Marengoni, Alessandra; Tettamanti, Mauro; Salerno, Francesco; Pasina, Luca; Franchi, Carlotta; Iorio, Alfonso; Marcucci, Maura; Corrao, Salvatore; Licata, Giuseppe; Mannucci, Pier Mannuccio.
In: European Journal of Internal Medicine, Vol. 22, No. 6, 12.2011, p. 597-602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between clusters of diseases and polypharmacy in hospitalized elderly patients
T2 - Results from the REPOSI study
AU - Nobili, Alessandro
AU - Marengoni, Alessandra
AU - Tettamanti, Mauro
AU - Salerno, Francesco
AU - Pasina, Luca
AU - Franchi, Carlotta
AU - Iorio, Alfonso
AU - Marcucci, Maura
AU - Corrao, Salvatore
AU - Licata, Giuseppe
AU - Mannucci, Pier Mannuccio
PY - 2011/12
Y1 - 2011/12
N2 - AbstractBackground Although the association between multimorbidity and polypharmacy has been clearly documented, no study has analyzed whether or not specific combinations of diseases influence the prescription of polypharmacy in older persons. We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients. Methods This cross-sectional study was held in 38 Italian internal medicine and geriatric wards participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The study sample included 1155 in-patients aged 65 years or older. Clusters of diseases, defined as two or more co-occurring specific chronic diseases, were identified using the odds ratio (OR) for the associations between pairs of diseases followed by cluster analysis. Polypharmacy was defined as the prescription of five or more different medications at hospital discharge. Logistic regression models were run to analyze the association between clusters of diseases and polypharmacy. Results Among clusters of diseases, the highest mean number of drugs (> 8) was found in patients affected by heart failure (HF) plus chronic obstructive pulmonary disease (COPD), HF plus chronic renal failure (CRF), COPD plus coronary heart disease (CHD), diabetes mellitus plus CRF, and diabetes mellitus plus CHD plus cerebrovascular disease (CVD). The strongest association between clusters of diseases and polypharmacy was found for diabetes mellitus plus CHD plus CVD, diabetes plus CHD, and HF plus atrial fibrillation (AF). Conclusions The observed knowledge of the relationship among co-occurring diseases and polypharmacy should help to identify and monitor older in-patients at risk of polypharmacy.
AB - AbstractBackground Although the association between multimorbidity and polypharmacy has been clearly documented, no study has analyzed whether or not specific combinations of diseases influence the prescription of polypharmacy in older persons. We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients. Methods This cross-sectional study was held in 38 Italian internal medicine and geriatric wards participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The study sample included 1155 in-patients aged 65 years or older. Clusters of diseases, defined as two or more co-occurring specific chronic diseases, were identified using the odds ratio (OR) for the associations between pairs of diseases followed by cluster analysis. Polypharmacy was defined as the prescription of five or more different medications at hospital discharge. Logistic regression models were run to analyze the association between clusters of diseases and polypharmacy. Results Among clusters of diseases, the highest mean number of drugs (> 8) was found in patients affected by heart failure (HF) plus chronic obstructive pulmonary disease (COPD), HF plus chronic renal failure (CRF), COPD plus coronary heart disease (CHD), diabetes mellitus plus CRF, and diabetes mellitus plus CHD plus cerebrovascular disease (CVD). The strongest association between clusters of diseases and polypharmacy was found for diabetes mellitus plus CHD plus CVD, diabetes plus CHD, and HF plus atrial fibrillation (AF). Conclusions The observed knowledge of the relationship among co-occurring diseases and polypharmacy should help to identify and monitor older in-patients at risk of polypharmacy.
KW - Cluster of diseases
KW - Hospitalized elderly
KW - Polypharmacy
UR - http://www.scopus.com/inward/record.url?scp=80855132637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80855132637&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2011.08.029
DO - 10.1016/j.ejim.2011.08.029
M3 - Article
C2 - 22075287
AN - SCOPUS:80855132637
VL - 22
SP - 597
EP - 602
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
SN - 0953-6205
IS - 6
ER -