Association between components of the insulin-like growth factor system and endometrial cancer risk

Livia S A Augustina, Luigino Dal Maso, Silvia Franceschi, Renato Talamini, Cyril W C Kendall, David J A Jenkins, Ed Vidgen, Carlo La Vecchia

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: The insulin-like growth factor (IGF) system has been related to cell proliferation, obesity, diabetes, hyperinsulinemia and endometrial cancer risk. We used data from a case-control study conducted in Italy to provide additional information on the relation between the IGF system and endometrial cancer. Methods: A casecontrol study was conducted between 1999 and 2002 in Italy, including a total of 73 women with incident, histologically confirmed endometrial cancer and 108 controls admitted to the same hospital network for acute, non-neoplastic diseases. All subjects were interviewed using a validated questionnaire. Results: The odds ratios for endometrial cancer comparing the highest versus the lowest tertile of various IGF components were as follows: 0.5 [95% confidence interval (CI) 0.2-1.2] for free IGF-I, 1.1 (95% CI 0.5-2.6) for total IGF-I, 1.2 (95% CI 0.6-2.6) for total IGF-II, 2.4 (95% CI 1.0-5.9) for IGF binding protein (IGFBP)-1 and 0.8 (95% CI 0.4-2.0) for IGFBP-3. Further allowance for all IGF components in the model did not modify the results. The direct relation with IGFBP-1 was stronger and limited to heavier and older women. Conclusions: The present findings suggest a limited effect of the IGF system on endometrial cancer risk. Increasing IGFBP-1 levels seem to be associated with endometrial cancer risk in older women and in women with a higher body mass index.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalOncology
Volume67
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint

Somatomedins
Endometrial Neoplasms
Insulin-Like Growth Factor Binding Protein 1
Confidence Intervals
Insulin-Like Growth Factor I
Italy
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Hyperinsulinism
Case-Control Studies
Body Mass Index
Obesity
Odds Ratio
Cell Proliferation

Keywords

  • Case-control study
  • Endometrial cancer
  • Insulin-like growth factor system
  • Obesity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Augustina, L. S. A., Dal Maso, L., Franceschi, S., Talamini, R., Kendall, C. W. C., Jenkins, D. J. A., ... La Vecchia, C. (2004). Association between components of the insulin-like growth factor system and endometrial cancer risk. Oncology, 67(1), 54-59. https://doi.org/10.1159/000080286

Association between components of the insulin-like growth factor system and endometrial cancer risk. / Augustina, Livia S A; Dal Maso, Luigino; Franceschi, Silvia; Talamini, Renato; Kendall, Cyril W C; Jenkins, David J A; Vidgen, Ed; La Vecchia, Carlo.

In: Oncology, Vol. 67, No. 1, 2004, p. 54-59.

Research output: Contribution to journalArticle

Augustina, LSA, Dal Maso, L, Franceschi, S, Talamini, R, Kendall, CWC, Jenkins, DJA, Vidgen, E & La Vecchia, C 2004, 'Association between components of the insulin-like growth factor system and endometrial cancer risk', Oncology, vol. 67, no. 1, pp. 54-59. https://doi.org/10.1159/000080286
Augustina, Livia S A ; Dal Maso, Luigino ; Franceschi, Silvia ; Talamini, Renato ; Kendall, Cyril W C ; Jenkins, David J A ; Vidgen, Ed ; La Vecchia, Carlo. / Association between components of the insulin-like growth factor system and endometrial cancer risk. In: Oncology. 2004 ; Vol. 67, No. 1. pp. 54-59.
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