Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk

Luigino Dal Maso, Livia S A Augustin, Silvia Franceschi, Renato Talamini, Jerry Polesel, Cyril W C Kendall, David J A Jenkins, Ed Vidgen, Carlo La Vecchia

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Components of the insulin-like growth factor (IGF) system have been associated with several cancers, but very few studies are available for ovarian cancer. Methods: A case-control study conducted between 1999 and 2003 in Italy, including a total of 59 women with incident, histologically confirmed ovarian cancer and 108 controls admitted to the same hospital network as cases, for acute non-neoplastic diseases. All subjects were interviewed using a validated questionnaire. Results: After adjustment for potential confounders, the multivariate odds ratios for the highest versus the lowest tertile of various IGF components were 0.6 (95% confidence interval, CI: 0.2-1.4) for free IGF-I, 0.4 (CI: 0.1-1.5) for total IGF-I, 2.6 (CI: 0.9-6.9) for IGF-binding protein (IGFBP)-1, and 0.2 (CI: 0.0-0.6) for IGFBP-3. Conclusions: This study suggests a protective role of IGFBP-3 and a positive association of IGFBP-1 with ovarian cancer. The complex role of the IGF system in ovarian carcinogenesis deserves further clarification.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalOncology
Volume67
Issue number3-4
DOIs
Publication statusPublished - 2004

Fingerprint

Somatomedins
Ovarian Neoplasms
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Italy
Case-Control Studies
Carcinogenesis
Odds Ratio
Confidence Intervals
Ovarian epithelial cancer
Neoplasms

Keywords

  • Case-control study
  • IGF-I
  • IGFBP-1
  • IGFBP-3
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dal Maso, L., Augustin, L. S. A., Franceschi, S., Talamini, R., Polesel, J., Kendall, C. W. C., ... Vecchia, C. L. (2004). Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. Oncology, 67(3-4), 225-230. https://doi.org/10.1159/000081322

Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. / Dal Maso, Luigino; Augustin, Livia S A; Franceschi, Silvia; Talamini, Renato; Polesel, Jerry; Kendall, Cyril W C; Jenkins, David J A; Vidgen, Ed; Vecchia, Carlo La.

In: Oncology, Vol. 67, No. 3-4, 2004, p. 225-230.

Research output: Contribution to journalArticle

Dal Maso, L, Augustin, LSA, Franceschi, S, Talamini, R, Polesel, J, Kendall, CWC, Jenkins, DJA, Vidgen, E & Vecchia, CL 2004, 'Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk', Oncology, vol. 67, no. 3-4, pp. 225-230. https://doi.org/10.1159/000081322
Dal Maso, Luigino ; Augustin, Livia S A ; Franceschi, Silvia ; Talamini, Renato ; Polesel, Jerry ; Kendall, Cyril W C ; Jenkins, David J A ; Vidgen, Ed ; Vecchia, Carlo La. / Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. In: Oncology. 2004 ; Vol. 67, No. 3-4. pp. 225-230.
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