Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk

Luigino Dal Maso, Livia S A Augustin, Silvia Franceschi, Renato Talamini, Jerry Polesel, Cyril W C Kendall, David J A Jenkins, Ed Vidgen, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Background: Components of the insulin-like growth factor (IGF) system have been associated with several cancers, but very few studies are available for ovarian cancer. Methods: A case-control study conducted between 1999 and 2003 in Italy, including a total of 59 women with incident, histologically confirmed ovarian cancer and 108 controls admitted to the same hospital network as cases, for acute non-neoplastic diseases. All subjects were interviewed using a validated questionnaire. Results: After adjustment for potential confounders, the multivariate odds ratios for the highest versus the lowest tertile of various IGF components were 0.6 (95% confidence interval, CI: 0.2-1.4) for free IGF-I, 0.4 (CI: 0.1-1.5) for total IGF-I, 2.6 (CI: 0.9-6.9) for IGF-binding protein (IGFBP)-1, and 0.2 (CI: 0.0-0.6) for IGFBP-3. Conclusions: This study suggests a protective role of IGFBP-3 and a positive association of IGFBP-1 with ovarian cancer. The complex role of the IGF system in ovarian carcinogenesis deserves further clarification.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalOncology
Volume67
Issue number3-4
DOIs
Publication statusPublished - 2004

Keywords

  • Case-control study
  • IGF-I
  • IGFBP-1
  • IGFBP-3
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Dal Maso, L., Augustin, L. S. A., Franceschi, S., Talamini, R., Polesel, J., Kendall, C. W. C., Jenkins, D. J. A., Vidgen, E., & Vecchia, C. L. (2004). Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. Oncology, 67(3-4), 225-230. https://doi.org/10.1159/000081322