Association between cutaneous melanoma and neurofibromatosis type 1: Analysis of three clinical cases and review of the literature

Gianfrancesco Gallino, Filiberto Belli, Gabrina Tragni, Franca Ferro, P. P B Massone, Antonino Ditto, Ermanno Leo, Natale Cascinelli

Research output: Contribution to journalArticle

Abstract

The authors report a rare association between cutaneous melanoma and Von Recklinghausen's disease (NF-1) and analyze the possible meaning of this occurrence. Various types of tumors have been associated with NF-1, in particular those of neuroectodermal origin, such as malignant peripheral nerve sheath tumors (MPNST) and phaeochromocytoma. The development of malignant melanoma in NF-1 patients is rare. Data from the literature is enable to demonstrate an increased incidence of cutaneous melanoma in patients with neurofibromatosis but the association of these two disorders seems reasonable in theory, as both are abnormalities of a neural crest origin. The cases described may represent not only a clinical report of two rarely associated disorders, but may also confirm the biological mechanisms responsible for these infrequent diseases.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalTumori
Volume86
Issue number1
Publication statusPublished - Jan 2000

Keywords

  • Cutaneous melanoma
  • Neural crest
  • Von Recklinghausen disease

ASJC Scopus subject areas

  • Cancer Research

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