Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status

C. Bombonato, S. Ribero, F. C. Pozzobon, J. A. Puig-Butille, C. Badenas, C. Carrera, J. Malvehy, E. Moscarella, Aimilios Lallas, S. Piana, S. Puig, G. Argenziano, C. Longo

Research output: Contribution to journalArticle

Abstract

Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.

Original languageEnglish
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
DOIs
Publication statusAccepted/In press - 2016

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Confocal Microscopy
Melanoma
Skin
Dermoscopy
Skin Neoplasms
Tertiary Care Centers
Multivariate Analysis
Logistic Models
Regression Analysis
Mutation

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status. / Bombonato, C.; Ribero, S.; Pozzobon, F. C.; Puig-Butille, J. A.; Badenas, C.; Carrera, C.; Malvehy, J.; Moscarella, E.; Lallas, Aimilios; Piana, S.; Puig, S.; Argenziano, G.; Longo, C.

In: Journal of the European Academy of Dermatology and Venereology, 2016.

Research output: Contribution to journalArticle

Bombonato, C. ; Ribero, S. ; Pozzobon, F. C. ; Puig-Butille, J. A. ; Badenas, C. ; Carrera, C. ; Malvehy, J. ; Moscarella, E. ; Lallas, Aimilios ; Piana, S. ; Puig, S. ; Argenziano, G. ; Longo, C. / Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status. In: Journal of the European Academy of Dermatology and Venereology. 2016.
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abstract = "Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.",
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AU - Bombonato, C.

AU - Ribero, S.

AU - Pozzobon, F. C.

AU - Puig-Butille, J. A.

AU - Badenas, C.

AU - Carrera, C.

AU - Malvehy, J.

AU - Moscarella, E.

AU - Lallas, Aimilios

AU - Piana, S.

AU - Puig, S.

AU - Argenziano, G.

AU - Longo, C.

PY - 2016

Y1 - 2016

N2 - Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.

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