Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status

C. Bombonato, S. Ribero, F. C. Pozzobon, J. A. Puig-Butille, C. Badenas, C. Carrera, J. Malvehy, E. Moscarella, Aimilios Lallas, S. Piana, S. Puig, G. Argenziano, C. Longo

Research output: Contribution to journalArticlepeer-review


Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.

Original languageEnglish
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Publication statusAccepted/In press - 2016

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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