Abstract
Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.
| Original language | English |
|---|---|
| Number of pages | 7 |
| Journal | Journal of the European Academy of Dermatology and Venereology |
| DOIs | |
| Publication status | Accepted/In press - 2016 |
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ASJC Scopus subject areas
- Dermatology
- Infectious Diseases
Cite this
Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status. / Bombonato, C.; Ribero, S.; Pozzobon, F. C.; Puig-Butille, J. A.; Badenas, C.; Carrera, C.; Malvehy, J.; Moscarella, E.; Lallas, Aimilios; Piana, S.; Puig, S.; Argenziano, G.; Longo, C.
In: Journal of the European Academy of Dermatology and Venereology, 2016.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status
AU - Bombonato, C.
AU - Ribero, S.
AU - Pozzobon, F. C.
AU - Puig-Butille, J. A.
AU - Badenas, C.
AU - Carrera, C.
AU - Malvehy, J.
AU - Moscarella, E.
AU - Lallas, Aimilios
AU - Piana, S.
AU - Puig, S.
AU - Argenziano, G.
AU - Longo, C.
PY - 2016
Y1 - 2016
N2 - Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.
AB - Background: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. Objectives: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status. Methods: Retrospectively acquired dermoscopic and confocal images of patients with melanoma in tertiary referral academic centres: Skin Cancer Unit in Reggio Emilia and at the Melanoma Unit in Barcelona. Kruskal-Wallis test, logistic regressions, univariate and multivariate analyses have been performed to find dermoscopic and confocal features significantly correlated with BRAF mutational status. Results: Dermoscopically, the presence of irregular peripheral streaks and ulceration were positive predictors of BRAF-mutated melanomas with a statistically significance value, while dotted vessels were more represented in wild-type melanomas. None of the evaluated reflectance confocal microscopy features were correlated with genetic profiling. Conclusions: Ulceration and irregular peripheral streaks represent dermoscopic feature indicative for BRAF-mutated melanoma, while dotted vessels are suggestive for wild-type melanoma.
UR - http://www.scopus.com/inward/record.url?scp=84995550260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995550260&partnerID=8YFLogxK
U2 - 10.1111/jdv.14028
DO - 10.1111/jdv.14028
M3 - Article
AN - SCOPUS:84995550260
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
ER -